Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel
Journal of Infectious Diseases, Volume 205, No. SUPPL. 2, Year 2012
Notification
URL copied to clipboard!
Description
There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis. © 2012 The Author.
Authors & Co-Authors
Graham, Stephen Michael
Unknown Affiliation
Ahmed, Tahmeed J.
Unknown Affiliation
Amanullah, Farhana
Unknown Affiliation
Browning, Renee S.
Unknown Affiliation
Cárdenas, Vicky
Unknown Affiliation
Casenghi, Martina
Unknown Affiliation
Eduardo Cuevas, Luis Eduardo
Unknown Affiliation
Gale, Marianne
Unknown Affiliation
Gie, Robert Peter
Unknown Affiliation
Grzemska, Malgorzata
Unknown Affiliation
Handelsman, Edward L.
Unknown Affiliation
Hatherill, Mark
Unknown Affiliation
Hesseling, Anneke Catharina
Unknown Affiliation
Jean-Philippe, Patrick
Unknown Affiliation
Kampmann, Beate B.
Unknown Affiliation
Kabra, Susheel Kumar
Unknown Affiliation
Lienhardt, Christian
Unknown Affiliation
Lighter-Fisher, Jennifer
Unknown Affiliation
Madhi, Shabir A.
Unknown Affiliation
Makhene, Mamodikoe K.
Unknown Affiliation
Marais, Ben J.
Unknown Affiliation
McNeeley, D. F.
Unknown Affiliation
Menzies, Heather J.
Unknown Affiliation
Mitchell, Charles D.
Unknown Affiliation
Modi, Surbhi
Unknown Affiliation
Mofenson, Lynne M.
Unknown Affiliation
Musoke, Philippa Martha
Unknown Affiliation
Nachman, Sharon A.
Unknown Affiliation
Powell, Clydette
Unknown Affiliation
Rigaud, Mona
Unknown Affiliation
Rouzier, Vanessa A.
Unknown Affiliation
Starke, Jeffrey Robert
Unknown Affiliation
Swaminathan, Soumya
Unknown Affiliation
Wingfield, C.
Unknown Affiliation
Statistics
Citations: 328
Authors: 34
Affiliations: 30
Identifiers
Doi:
10.1093/infdis/jis008
ISSN:
00221899
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study