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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antioxidant, antibacterial and cytotoxic effects of the phytochemicals of whole Leucas aspera extract
Asian Pacific Journal of Tropical Biomedicine, Volume 3, No. 4, Year 2013
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Description
Objective: To investigate the antioxidant, antibacterial and cytotoxic activity of whole Leucas aspera (Labiatae) (L. aspera) alcoholic extract. Methods: Whole L. aspera powder was extracted by absolute ethanol (99.50%). The ethanolic extract was subjected to antioxidant, antibacterial and brine shrimp lethality assay. Results: The extract showed potent radical scavenging effect (antioxidant) with IC
50
value of (99.58±1.22) μg/mL which was significant (P<0.01) in comparison to ascorbic acid with IC
50
value of (1.25±0.95) μg/mL. In case of antibacterial screening, the extract showed notable antibacterial effect against the tested microbial strains. Significant (P<0.05) zone of inhibitions against Gram positive Bacillus subtilis [(12.00±1.32) mm] and Bacillus megaterium [(13.00±1.50) mm], Staphylococcus aureus [(8.00±0.50) mm] and Gram negative Salmonella typhi [(6.00±0.50) mm], Salmonella paratyphi [(8.00±1.00) mm], Shigella dysenteriae [(9.00±1.32) mm] and Vibrio cholerae [(9.00±0.66) mm] was observed. In brine shrimp lethality bioassay, the extract showed the LC
50
value as (181.68±2.15) μg/mL which was statistically significant (P<0.01) compared to positive control vincristine sulfate [LC
50
=(0.76±0.04) μg/mL]. Conclusions: The results demonstrate that the ethanolic extract of L. aspera could be used as antibacterial, pesticidal and various pharmacologic actives. © 2013 Asian Pacific Tropical Biomedical Magazine.
Authors & Co-Authors
Rahman, Md Atiar
Bangladesh, Chittagong
University of Chittagong
South Africa, Durban
University of Kwazulu-natal
Islam, Md Saiful
Bangladesh, Chittagong
University of Chittagong
Statistics
Citations: 46
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/S2221-1691(13)60062-3
ISSN:
22211691
Research Areas
Infectious Diseases