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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IL-4Rα-responsive smooth muscle cells contribute to initiation of T
H
2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections
Mucosal Immunology, Volume 4, No. 1, Year 2011
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Description
Nippostrongylus brasiliensis infections generate pulmonary pathologies that can be associated with strong TH2 polarization of the host's immune response. We present data demonstrating N. brasiliensis-driven airway mucus production to be dependent on smooth muscle cell interleukin 4 receptor-α (IL-4Rα) responsiveness. At days 7 and 10 post infection (PI), significant airway mucus production was found in IL-4Rα /lox control mice, whereas global knockout (IL-4Rα /) and smooth muscle-specific IL-4Rα- deficient mice (SM-MHC Cre IL-4Rα /lox) showed reduced airway mucus responses. Furthermore, interleukin (IL)-13 and IL-5 cytokine production in SM-MHC Cre IL-4Rα /lox mice was impaired along with a transient reduction in T-cell numbers in the lung. In vitro treatment of smooth muscle cells with secreted N. brasiliensis excretory-secretory antigen (NES) induced IL-6 production. Decreased protein kinase C (PKC)-dependent smooth muscle cell proliferation associated with cell cycle arrest was found in cells stimulated with NES. Together, these data demonstrate that both IL-4Rα and NES-driven responses by smooth muscle cells make important contributions in initiating TH2 responses against N. brasiliensis infections. © 2011 Society for Mucosal Immunology.
Authors & Co-Authors
Horsnell, William Gordon Charles
South Africa, Cape Town
University of Cape Town
Vira, Alykhan
South Africa, Cape Town
University of Cape Town
Kirstein, Frank
South Africa, Cape Town
University of Cape Town
Mearns, Helen
South Africa, Cape Town
University of Cape Town
New Zealand, Wellington
Victoria University of Wellington
Hoving, Jennifer Claire
South Africa, Cape Town
University of Cape Town
Cutler, Antony J.
South Africa, Cape Town
University of Cape Town
United Kingdom, Bristol
Nhs Blood and Transplant
Dewals, Benjamin G.
South Africa, Cape Town
University of Cape Town
Myburgh, Elmarie
South Africa, Cape Town
University of Cape Town
United Kingdom, Glasgow
University of Glasgow
Kimberg, Matti
South Africa, Cape Town
University of Cape Town
Arendse, Berenice
South Africa, Cape Town
University of Cape Town
White, Nicole M.
South Africa, Cape Town
University of Cape Town
Lopata, Andreas Ludwig
South Africa, Cape Town
University of Cape Town
Australia, Melbourne
Rmit University
Burger, Patricia E.
South Africa, Cape Town
University of Cape Town
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 32
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1038/mi.2010.46
ISSN:
19330219