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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage
Malaria Journal, Volume 10, Article 52, Year 2011
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Description
Background: The adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of malaria. Atorvastatin, a drug that belongs to the lowering cholesterol molecule family of statins, has been shown to ameliorate endothelial functions and is widely used in patients with cardiovascular disorders. Methods. The effect of this compound on PRBC induced endothelial impairments was assessed using endothelial co-culture models. Results: Atorvastatin pre-treatment of EC was found to reduce the expression of adhesion molecules and P. falciparum cytoadherence, to protect cells against PRBC-induced apoptosis and to enhance endothelial monolayer integrity during co-incubation with parasites. Conclusions: These results might suggest a potential interest use of atorvastatin as a protective treatment to interfere with the pathophysiological cascades leading to severe malaria. © 2011 Taoufiq et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Taoufiq, Zacharie
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Japan, Okinawa
Okinawa Institute of Science and Technology Graduate University
Pino, Paco
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Switzerland, Geneva
Université de Genève
N'Dilimabaka, Nadine
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Arrouss, Issam
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Assi, Serge Brice
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Cote D'ivoire, Abidjan
Institut National de Sante Publique Abidjan
Soubrier, Florent
France, Paris
Inserm
Rebollo, Angelita
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Mazier, Dominique
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 45
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1186/1475-2875-10-52
e-ISSN:
14752875
Research Areas
Cancer
Infectious Diseases
Noncommunicable Diseases