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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The toll-like receptor 4 Asp299Gly variant: No influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia
Tuberculosis, Volume 84, No. 6, Year 2004
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Description
Setting: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide. Studies in a murine model of pulmonary TB have identified a role for Toll-like receptor 4 (TLR4) in the development of chronic lung infection with Mycobacterium tuberculosis. The Asp299Gly polymorphism in the human TLR4 gene is associated with in vivo hyporesponsiveness to lipopolysaccharide (LPS) in Caucasians. Objective: To determine whether TLR4 Asp299Gly influences LPS responses or susceptibility to pulmonary TB in humans in a Gambian population sample. Design: We compared whole blood monokine responses to LPS in 245 healthy blood donors stratified by TLR4 Asp299Gly genotype to assess whether this polymorphism was functional in this population. A case-control study of 640 subjects was conducted to investigate whether TLR4 Asp299Gly was associated with TB. Results: LPS-induced tumour necrosis factor, interleukin-1β and interleukin-10 production was not influenced by TLR4 Asp299Gly genotype. There was no association between TLR4 Asp299Gly and TB. Conclusion: Our data suggest that TLR4 Asp299Gly has no influence on monocyte LPS responses or susceptibility to TB in Gambians and could be an ancient neutral polymorphism. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Newport, Melanie J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Allen, Angela
Gambia, Banjul
Medical Research Council Laboratories Gambia
Awomoyi, Agnes A.O.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Dunstan, Sarah J.
Viet Nam, Ho Chi Minh City
Centre for Tropical Diseases Vietnam
McKinney, E.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Marchant, Arnaud
Gambia, Banjul
Medical Research Council Laboratories Gambia
Belgium, Brussels
Lab. of Experimental Immunology
Sirugo, G.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 93
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.tube.2004.02.001
ISSN:
14729792
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Gambia