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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sickle-cell disease in Malawian children is associated with restrictive spirometry: A cross-sectional survey
International Journal of Tuberculosis and Lung Disease, Volume 17, No. 9, Year 2013
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Description
BACKGROUND: A proportion of children with sicklecell disease (SCD) demonstrate clinical findings consistent with the diagnosis of asthma. These children are at increased risk of complications, including acute chest syndrome. OBJECTIVE: To assess lung function and symptoms of asthma in children with SCD in Blantyre, Malawi. DESIGN: Twenty-five children aged 7-16 years with electrophoretically confirmed SCD were recruited to u ndergo spirometry and questionnaire screening of asthma symptoms. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio were compared with local and international reference ranges. Symptoms were assessed using the International Study of Asthma and Allergies in Childhood questionnaire. RESULTS: Mean spirometric indices, represented as Zscores derived from international reference ranges, were low: FEV1 -1.64 (95%CI -2.04 to -1.23), FVC -1.49 (95%CI -1.90 to -1.09), FEV1/FVC -0.39 (95%CI -0.76 to -0.03). Comparison with local reference ranges, represented as percentage of predicted value, revealed similar impairments: FEV1 86.9 (95%CI 81.1 to 92.7), FVC 89.0 (95%CI 83.5 to 94.4), FEV1/FVC ratio 97.7 (95%CI 95.4 to 99.9). The prevalence of wheeze was 16.7%. CONCLUSION: We present spirometric abnormalities suggestive of restrictive lung disease with no evidence of obstructive defects or increased prevalence of wheeze. © 2013 The Union.
Authors & Co-Authors
Cook, J.
United Kingdom, London
Lewisham and Greenwich Nhs Trust
Jefferis, Oliver
United Kingdom, Blantyre
Queen Elizabeth Central Hospital
Matchere, P.
United Kingdom, Blantyre
Queen Elizabeth Central Hospital
Mbale, Emmie W.
United Kingdom, Blantyre
Queen Elizabeth Central Hospital
Rylance, Jamie
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 13
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.5588/ijtld.12.0965
ISSN:
10273719
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Malawi