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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Chikungunya outbreak in a rural area of Western Cameroon in 2006: A retrospective serological and entomological survey
BMC Research Notes, Volume 3, Article 128, Year 2010
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Description
Background: Although arboviral infections including Chikungunya virus (CHIKV) are common in sub-Saharan Africa, data on their circulation and prevalence are poorly documented. In 2006, more than 400 cases of dengue-like fever were reported in Kumbo (Northwest Region of Cameroon). The aim of this study was to identify the aetiology of this fever and to define its extent in the area. Methods: We conducted a cross-sectional seroprevalence survey one year after clinical investigations to define the extent of the infection. An entomological survey consisted of the collection and identification of mosquito immature stages in water containers in or around human dwellings. Results: A total of 105 sera were obtained from volunteers and tested for CHIKV, O'Nyong-nyong virus (ONNV) and Dengue virus (DENV) specific IgM and IgG antibodies by enzyme-linked immunosorbent assays (ELISA). CHIKV infection was defined as the presence of IgM antibodies to CHIKV. There was serological evidence for recent Chikungunya infection, as 54 subjects (51.4%) had detectable IgM anti-CHIKV in their sera. Amongst these, 52 showed both anti-CHIKV IgM and IgG, and 2 (1.9%) had IgM anti-CHIKV in the absence of IgG. Isolated anti-CHIKV IgG positives were detected in 41 (39%) cases. No anti-ONNV and anti-DENV IgM antibodies were found amongst the sample tested. Out of 305 larvae collected in the different breeding sites, 87 developed to the adult stage; 56 (64.4%) were Aedes africanus and the remaining Culex spp. Conclusions: These findings suggest that the outbreak of febrile illness reported in three villages of Western Cameroon was due to CHIKV. The issue of a possible persistence of anti-CHIKV IgM antibodies is discussed. Ae. africanus which was found to be relatively abundant among the raffia palm bushes probably plays a role in the transmission of CHIKV along the chain of sylvatic/domestic mosquito species in this rural area. Particular attention should therefore be given to arbovirus infections in the Central African sub-region where these infections are becoming an emerging public health threat. © 2010 Demanou et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Demanou, Maurice
Cameroon, Yaounde
Centre Pasteur du Cameroun
Antonio-Nkondjio, Christophe
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale Cameroon
Ngapana, Emmanuel
Cameroon, Yaounde
Comité National D'epidémiologie du Cameroun
Rousset, Dominique
Cameroon, Yaounde
Centre Pasteur du Cameroun
Paupy, Christophe
Cameroon
Institut de Recherche Pour le Développement Ird
Manuguerra, Jean Claude
France, Paris
Institut Pasteur, Paris
Zeller, Hervé G.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 67
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1186/1756-0500-3-128
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Cameroon