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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Two years of intrauterine contraception with levonorgestrel and with copper: A randomized comparison of the TCu 380Ag and levonorgestrel 20 mcg/day device
Contraception, Volume 35, No. 3, Year 1987
Notification
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Description
IUDs releasing 20 mcg/day of levonorgestrel (LNg20) were in randomized trial together with the Copper T, model TCu 380Ag, in seven centers involving 2244 women. Two-year (25 months) gross cumulative pregnancy rates were 0.2 ± 0.2 and 0.9 ± 0.3 for the levonorgestrel and copper releasing devices, respectively (P > 0.05). There were no ectopic pregnancies in more than 1600 woman-years of use of each device. Removal rates for bleeding and/or pain or for medical reasons other than menstrual problems did not differ significantly between devices. Oligomenorrhea or amenorrhea prompted 10.7 per hundred (gross rate, 8.4 net rate) women using the LNg 20 IUD to request removal in the two-year period, significantly above the 0.2 per hundred rate among women with the Copper IUD (P < 0.001). At the end of two years an estimated 59.4 per 100 women were continuing use of the LNg 20 IUD, and 67.5 per 100 (P < 0.001) with the TCu 380Ag. This difference is almost wholly ascribable to a marked reduction in bleeding episodes and days among women using the LNg 20 device with concomitant removal of device. Hemoglobin rose an average of 0.5g/dl (P < 0.001) for this group whereas women using the TCu 380Ag experienced a decline of 0.2g/dl compared with baseline values (P < 0.001). © 1987.
Authors & Co-Authors
Sivin, Irving
United States, New York
The Population Council, Inc.
Stern, Janet
United States, New York
The Population Council, Inc.
Díaz, Juan José
Brazil, Campinas
Center for Mother and Child Research of Campinas
Diaz, M. Margarita
Brazil, Campinas
Center for Mother and Child Research of Campinas
Faúndes, Aníbal E.
Brazil, Campinas
Center for Mother and Child Research of Campinas
El-Mahgoub, Sayed
Egypt, Cairo
Ain Shams University
Díaz, Soledad
Chile, Santiago
Instituto Chileno de Medicina Reproductiva
Pavez, Margarita
Chile, Santiago
Instituto Chileno de Medicina Reproductiva
Coutinho, Elsimar Metzker
Brazil, Salvador
Universidade Federal da Bahia
Mattos, Carlos E.R.De
Brazil, Salvador
Universidade Federal da Bahia
McCarthy, Terry
Singapore, Singapore City
National University of Singapore
Mishell, Daniel R.J.
United States, Los Angeles
Keck School of Medicine of Usc
Shoupe, Donna
United States, Los Angeles
Keck School of Medicine of Usc
Alvarez-Sánchez, Francisco
Dominican Republic, Santo Domingo
Profamilia
Brache, Vivian
Dominican Republic, Santo Domingo
Profamilia
Jimenez, Elvira
Dominican Republic, Santo Domingo
Profamilia
Statistics
Citations: 71
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1016/0010-7824(87)90026-6
ISSN:
00107824
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female