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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936
Neurobiology of Aging, Volume 42, Year 2016
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Description
We aimed to determine associations between multiple vascular risk factors (VRF) at ~73 years and progression of white matter hyperintensities (WMH) from ~73 years to ~76 years. We calculated correlations and generalized estimating equation models of a comprehensive range of VRF at 73 years and change in WMH volume from 73 years to 76 years. Higher systolic (rho = 0.126, p = 0.009) and diastolic (rho = 0.120, p = 0.013) blood pressure at 73 years were significant predictors for greater WMH volume at 76 years in a simple correlation model. However, neither measured blood pressure nor self-reported hypertension at 73 years was significant predictors of WMH volume change in a fully adjusted model which accounted for initial WMH volume at 73 years. Lower high-density lipoprotein cholesterol (beta = -0.15 % intracranial, -1.80 mL; p < 0.05) and current smoking (beta = 0.43 % intracranial, 5.49 mL; p < 0.05) were the only significant VRF predictors of WMH volume change from 73 years to 76 years. A focus on smoking cessation and lipid lowering, not just antihypertensives, may lead to a reduction in WMH growth in the eighth decade of life. © 2016 The Authors.
Authors & Co-Authors
Dickie, David Alexander
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Ritchie, Stuart J.
United Kingdom, Edinburgh
The University of Edinburgh
Cox, Simon R.
United Kingdom, Edinburgh
The University of Edinburgh
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Aribisala, Benjamin Segun
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Valdés-Hernández, Maria Del Carmen
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Muñoz Maniega, Susana
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Pattie, Alison
United Kingdom, Edinburgh
The University of Edinburgh
Corley, Janie
United Kingdom, Edinburgh
The University of Edinburgh
Starr, John M.
United Kingdom, Edinburgh
The University of Edinburgh
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Glasgow
Scottish Imaging Network
Statistics
Citations: 63
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1016/j.neurobiolaging.2016.03.011
ISSN:
01974580
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study