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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Psychiatric symptoms and mortality in older adults with major psychiatric disorders: results from a multicenter study
European Archives of Psychiatry and Clinical Neuroscience, Volume 273, No. 3, Year 2023
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Description
Prior research suggests that certain psychiatric symptoms could be associated with increased risk of death. However, it remains unclear whether this association could rely on all or specific symptoms. In this report, we used data from a multicenter 5-year prospective study (N = 641) of older adults with an ICD-10 diagnosis of schizophrenia, bipolar disorder or major depressive disorder, recruited from French community psychiatric departments. We used a latent variable approach to disentangle the effects shared by all psychiatric symptoms (i.e., general psychopathology factor) and those specific to individual psychiatric symptoms, while adjusting for sociodemographic and clinical factors. Psychiatric symptoms were assessed face-to-face by psychiatrists trained to semi-structured interviews using the Brief Psychiatric Rating Scale (BPRS). Among older adults with major psychiatric disorders, we found that all psychiatric symptoms were associated with increased mortality, and that their effect on the 5-year mortality were exerted mostly through a general psychopathology dimension (β = 0.13, SE = 0.05, p < 0.05). No BPRS item or lower order factor had a significant effect on mortality beyond and above the effect of the general psychopathology factor. Greater number of medical conditions, older age, male sex, and being hospitalized or institutionalized at baseline were significantly associated with this risk beyond the effect of the general psychopathology factor. Since psychiatric symptoms may affect mortality mainly through a general psychopathology dimension, biological and psychological mechanisms underlying this dimension should be considered as promising targets for interventions to decrease excess mortality of older individuals with psychiatric disorders. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Authors & Co-Authors
Sánchez-Rico, Marina
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Spain, Madrid
Universidad Complutense de Madrid
Blanco, Carlos V.
United States, Bethesda
National Institute on Drug Abuse Nida
Hoertel, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
France, Paris
Université Paris Cité
Adès, Jean
Unknown Affiliation
Amado, Isabelle Reine
Unknown Affiliation
Dubertret, Caroline
Unknown Affiliation
Guillin, Olivier
Unknown Affiliation
Haffen, Emmanuel
Unknown Affiliation
Jalenques, Isabelle
Unknown Affiliation
Kébir, Oussama
Unknown Affiliation
Krebs, Marie Odile
Unknown Affiliation
Leboyer, Marion
Unknown Affiliation
Llorca, Pierre Michel
Unknown Affiliation
Mahi, Mohammed
Unknown Affiliation
Nubukpo, Philippe
Unknown Affiliation
Pringuey, Dominique J.
Unknown Affiliation
Sechter, Daniel
Unknown Affiliation
Verdoux, Hélène
Unknown Affiliation
Statistics
Citations: 3
Authors: 18
Affiliations: 6
Identifiers
Doi:
10.1007/s00406-022-01426-4
ISSN:
09401334
Research Areas
Mental Health
Study Design
Cohort Study
Participants Gender
Male