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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Anti-plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine
Phytotherapy Research, Volume 18, No. 5, Year 2004
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Description
Sixty organic and aqueous extracts of eleven plants used for the control of malaria by local communities in Kisii District, Kenya were screened for in vitro anti-plasmodial activity. The plants selection was based on existing ethnobotanical information and interviews with local communities. The extracts were tested against chloroquine sensitive and resistant laboratory adapted strains of Plasmodium falciparum. The study revealed that 63.6% of the plants were active (IC50≤100μg/mL). Extracts of four plants, Ekebergia capensis, Stephania abyssinica, Ajuga remota and Clerodendrum myricoides gave IC50 values below 30 μg/mL against both chloroquine sensitive and resistant P. falciparum strains. Combination of extracts of E. capensis and C. myricoides with chloroquine against the multi-drug resistant P. falciparum isolate (V1/S) revealed synergistic effect. The plants which showed activity may be useful as sources for novel anti-plasmodial compounds. Copyright © 2004 John Wiley & Sons, Ltd.
Authors & Co-Authors
Muregi, Francis Wamakima
Kenya, Nairobi
Kenyatta University
Chhabra, Sumesh Chander
Kenya, Nairobi
Kenyatta University
Njagi, Eliud Nyaga Mwaniki
Kenya, Nairobi
Kenyatta University
Lang'at-Thoruwa, C. C.
Kenya, Nairobi
Kenyatta University
Njue, W. M.
Kenya, Nairobi
Kenyatta University
Orago, Alloys S.S.
Kenya, Nairobi
Kenyatta University
Omar, Sabah Ahmed
Kenya, Nairobi
Kenya Medical Research Institute
Ndiege, Isaiah Omolo
Kenya, Nairobi
Kenyatta University
Statistics
Citations: 88
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1002/ptr.1439
ISSN:
0951418X
Research Areas
Infectious Diseases
Study Locations
Kenya