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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genital types of papillomavirus in children of women with HIV‐1 infection in Kinshasa, Zaire
International Journal of Cancer, Volume 54, No. 2, Year 1993
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Description
Increasing evidence indicates that infection with genital types of human papillomavirus (HPV) can occur prior to the onset of sexual activity, possibly by perinatal transmission. Evidence is also accumulating that women infected with the human immunodeficiency virus (HIV) more frequently express HPV. We conducted this study to measure HPV prevalence in HIV‐seropositive and ‐seronegative women in Kinshasa, Zaire and in their children. We collected cervico‐vaginal lavage specimens from 80 mothers (52 HIV‐seropositive and 28 HIV‐seronegative at the time of delivery) and oropharyngeal and perineal specimens from their 81 3‐year old children (21 HIV‐seropositive and 60 ‐seronegative). We used the ViraPap and ViraType assay to test specimens for HPV DNA by the dot‐blot technique. Detection of HPV in the mother was highly associated with HIV: 20 HIV‐seropositive women and one seronegative woman had HPV DNA. Ten children had HPV DNA. However, detection of HPV in the children was not associated with the mothers' HPV or HIV status or with the child's own HIV status. These findings document a substantial prevalence in young children of HPV DNA types that are linked to genital‐tract neoplasia in adults, but do not specifically support a hypothesis of mother‐to‐child transmission of genital HPV types. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Louis, Michael E.St
Congo
Sida
United States, Atlanta
National Center for Infectious Diseases
Kamenga, M.
Congo
Sida
Ryder, Robert W.
Congo
Sida
Heyward, William L.
Congo
Sida
United States, Atlanta
National Center for Infectious Diseases
Icenogle, Joseph P.
United States, Atlanta
National Center for Infectious Diseases
Reeves, William C.
United States, Atlanta
National Center for Infectious Diseases
Manzila, Tarande
Congo
Sida
Democratic Republic Congo
Clinique Ngaliema
Statistics
Citations: 14
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1002/ijc.2910540203
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Female