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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis
European Journal of Immunology, Volume 41, No. 7, Year 2011
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Description
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's largest infectious disease problems. Despite decades of intensive study, the immune response to Mtb is incompletely characterised, reflecting the extremely complex interaction between pathogen and host. Pathways that may alter the balance between host protection and pathogenesis are therefore of great interest. One pathway shown to play a role in the pathogenesis of chronic infections, including TB, is the programmed death-1 (PD-1) pathway. We show here that the expression of the programmed death ligand 1 (PD-L1), which interacts with PD-1, is increased in whole blood from active TB patients compared with whole blood from healthy controls or Mtb-exposed individuals, and that expression by neutrophils is largely responsible for this increase. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3179592/bin/eji0041-1941-SD1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3179592/bin/eji0041-1941-SD2.pdf
Authors & Co-Authors
Mcnab, Finlay W.
United Kingdom, London
Mrc National Institute for Medical Research
Berry, Matthew P.R.
United Kingdom, London
Mrc National Institute for Medical Research
United Kingdom, London
Imperial College Healthcare Nhs Trust
Graham, Christine Marian
United Kingdom, London
Mrc National Institute for Medical Research
Bloch, Susannah A.A.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Oni, Tolu
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Imperial College London
Andrea Wilkinson, Katalin Andrea
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Mrc National Institute for Medical Research
Wilkinson, Robert J.
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Imperial College London
United Kingdom, London
Mrc National Institute for Medical Research
Kon, Onn Min
United Kingdom, London
Imperial College Healthcare Nhs Trust
Banchereau, Jacques F.J.
United States, Nutley
Hoffmann-la Roche Inc.
Chaussabel, Damien
United States, Dallas
Baylor Institute for Immunology Research
United States, Seattle
Benaroya Research Institute at Virginia Mason
O’Garra, Anne
United Kingdom, London
Mrc National Institute for Medical Research
Statistics
Citations: 103
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1002/eji.201141421
e-ISSN:
15214141
Research Areas
Infectious Diseases