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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Polyhexamethylene guanidine hydrochloride-based disinfectant: A novel tool to fight meticillin-resistant Staphylococcus aureus and nosocomial infections
Journal of Medical Microbiology, Volume 57, No. 12, Year 2008
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Description
Polyhexamethylene guanidine hydrochloride (PHMGH), an antimicrobial biocide of the guanidine family, was tested for efficacy against quality-control strains of Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella choleraesuis, meticillin-resistant S. aureus (MRSA) and Escherichia coli. Bactericidal activity against S. aureus, P. aeruginosa and Salmonella choleraesuis was determined using the official methods of analysis of the Association of Official Analytical Chemists, with modifications as recommended by the Canadian General Standards Board. For MRSA and E. coli, the MIC and minimal bactericidal concentration were determined using the broth dilution technique. The experiments were carried out at 20°C under a range of conditions including varying PHMGH concentration (0.001-0.1 %), contact time (0.5-10 min) and water type (distilled, tap and hard water). The phenol coefficient values determined with S. aureus, Salmonella choleraesuis and P. aeruginosa were 7.5, 6.1 and 5, respectively. No matter what type of water was used to make the dilutions, PHMGH killed MRSA and E. coli at concentrations as low as 0.04 and 0.005% (w/v), respectively, within 1.5 min. The mode of action of PHMGH was elucidated by transmission electron microscopy: the cell envelope was broken, resulting in cell content leakage into the medium. The ultimate aim of this study was to show that PHMGH can be used as an odourless, colourless, non-corrosive and harmless disinfectant for hospital and household facilities. © 2008 SGM.
Authors & Co-Authors
Oulé, Mathias Kégnon
Canada, Winnipeg
Université de Saint-boniface
Azinwi, Richard
Canada, Winnipeg
Université de Saint-boniface
Bernier, Anne Marie
Canada, Winnipeg
Université de Saint-boniface
Tano, Kablan
Cote D'ivoire, Abidjan
University of Abobo-adjamé
Maupertuis, Anne Marie
Canada, Winnipeg
Université de Saint-boniface
Mauler, Stephanie
Canada, Winnipeg
Université de Saint-boniface
Nevry, Rose Koffi
Cote D'ivoire, Abidjan
University of Abobo-adjamé
Dembélé, Korami
Canada, Winnipeg
Université de Saint-boniface
Forbes, Lorraine
Canada, Winnipeg
Université de Saint-boniface
Diop, Lamine A.
Canada, Winnipeg
Université de Saint-boniface
Statistics
Citations: 134
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1099/jmm.0.2008/003350-0
ISSN:
00222615
Research Areas
Environmental
Health System And Policy
Infectious Diseases