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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Pharmacological basis for the medicinal use of Holarrhena antidysenterica in gut motility disorders
Pharmaceutical Biology, Volume 48, No. 11, Year 2010
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Description
Context: Holarrhena antidysenterica Wall. (Apocynaceae) is widely used in traditional medical system for treatment of constipation, colic, and diarrhea. Aim: This study was carried out to provide pharmacological basis for medicinal use of Holarrhena antidysenterica in gastrointestinal disorders. Materials and methods: Hydro-ethanolic crude extract of Holarrhena antidysenterica (HaCE) and its fractions were studied in various gastrointestinal isolated tissue preparations. Results: In guinea pig ileum tissues, HaCE at 0.3-10mg/mL caused pyrilamine-sensitive spasmogenic effect. When tested in spontaneously contracting rabbit jejunum preparations, HaCE (0.01-3.0mg/mL) caused moderate stimulation, followed by a relaxant effect at next higher concentrations. In presence of pyrilamine, the contractile effect was blocked and the relaxation was observed at lower concentrations (0.01-0.3mg/mL). HaCE inhibited the high K+ (80mM)-induced contractions at concentration range of 0.01-1.0mg/mL and shifted Ca++ concentration response curves to the right, like that caused by verapamil. Activity-directed fractionation revealed that the spasmogenic component was concentrated in the aqueous fraction, while the spasmolytic component was concentrated in the organic fraction. Discussion and conclusion: These results indicate that the gut stimulant and relaxant activities of Holarrhena antidysenterica are mediated possibly through activation of histamine receptors and Ca++ channel blockade, respectively and this study provides sound mechanistic background for its usefulness in gut motility disorders such as constipation, colic, and possibly diarrhea. © 2010 Informa Healthcare USA, Inc.
Authors & Co-Authors
Gilani, Anwar ul Hassan
Pakistan, Karachi
The Aga Khan University Medical College
Saudi Arabia, Riyadh
King Saud University
Khan, Aslam
Pakistan, Karachi
The Aga Khan University Medical College
Pakistan, Karachi
University of Karachi
Khan, Arifullah
Pakistan, Karachi
The Aga Khan University Medical College
Pakistan, Kohat
Kohat University of Science and Technology Kust
Bashir, Samra
Pakistan, Karachi
The Aga Khan University Medical College
Pakistan, Multan
Bahauddin Zakariya University
Rehman, Najeeb Ur
Pakistan, Karachi
The Aga Khan University Medical College
Mandukhail, Saf Ur Rehman
Pakistan, Karachi
The Aga Khan University Medical College
Statistics
Citations: 41
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.3109/13880201003727960
ISSN:
13880209
e-ISSN:
17445116
Research Areas
Health System And Policy
Study Locations
Guinea