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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Effects of magnesium on ischemic and reperfusion arrhythmias in the rat heart and electrophysiologic effects of hypermagnesemia in the anesthetized dog
Cardiovascular Drugs and Therapy, Volume 2, No. 5, Year 1988
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Description
Magnesium sulfate, reportedly clinically effective against some ventricular arrhythmias, has not been extensively studied for its effects on experimental ischemic and reperfusion arrhythmias. We evaluated the effects of three high extracellular concentrations of magnesium (Mg2+) 1.19, 2.38, and 4.76 mM in 70 isolated perfused rat hearts following coronary artery ligation and peperfusion, at each of three different perfusate ionized calcium (Ca2+) concentrations (0.9, 1.25, and, 2.5 mM), where 1.25 mM is close to physiologic. At 0.9 mM Ca2+, higher concentrations of Mg2+ increased the sinus node cycle length (p<0.02) and virtually abolished ischemic ventricular tachycardia (VT) and reperfusion ventricular fibrillation (VF) (p<0.01), otherwise consistently found in this model. At 1.25 and 2.5 mM Ca2+ increasing Mg2+ had no effect on the incidence of ischemic or reperfusion arrhythmias, although at 1.25 mM Ca2+ ischemic VT had longer cycle lengths and VT appeared after a longer delay (p<0.01). In the nonischemic dog heart, marked increases of serum Mg2+ progressively prolonged the A-H, H-V, and QR S intervals, the ventricular effective refractory period, and the sinus cycle length, while the arterial blood pressure fell. Because of its relatively modest electrophysiologic and hemodynamic effects, it is inferred that intravenous magnesium may be given therapeutically with relative safety. © 1988 Kluwer Academic Publishers.
Authors & Co-Authors
Keren, André
United States, Stanford
Falk Cardiovascular Research Center
Dorian, Paul
United States, Stanford
Falk Cardiovascular Research Center
Davy, Jean Marc
United States, Stanford
Falk Cardiovascular Research Center
Opie, LionelH H.
United States, Stanford
Falk Cardiovascular Research Center
Statistics
Citations: 8
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1007/BF00054203
ISSN:
15737241
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study