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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Modeling HIV transmission risk among Mozambicans prior to their initiating highly active antiretroviral therapy
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Volume 19, No. 5, Year 2007
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Description
Understanding sexual behavior and assessing transmission risk among people living with HIV-1 is crucial for effective HIV-1 prevention. We describe sexual behavior among HIV-positive persons initiating highly active antiretroviral therapy (HAART) in Beira, Mozambique. We present a Bernoulli process model (tool available online) to estimate the number of sexual partners who would acquire HIV-1 as a consequence of sexual contact with study participants within the prior three months. Baseline data were collected on 350 HAART-naive individuals 18-70 years of age from October 2004 to February 2005. In the three months prior to initiating HAART, 45% (n = 157) of participants had sexual relationships with 191 partners. Unprotected sex occurred in 70% of partnerships, with evidence suggesting unprotected sex was less likely with partners believed to be HIV-negative. Only 26% of the participants disclosed their serostatus to partners with a negative or unknown serostatus. Women were less likely to report concurrent relationships than were men (21 versus 66%; OR 0.13; 95%CI: 0.06, 0.26). Given baseline behaviors, the model estimated 23.2 infections/1,000 HIV-positive persons per year. The model demonstrated HAART along with syphilis and herpes simplex virus type 2 (HSV-2) treatment combined could reduce HIV-1 transmission by 87%; increasing condom use could reduce HIV-1 transmission by 67%. © 2007 Taylor & Francis.
Authors & Co-Authors
Pearson, Cynthia R.
United States, Seattle
University of Washington
Kurth, Ann Elizabeth
United States, Seattle
University of Washington
Cassels, Susan L.
United States, Seattle
University of Washington
Martin, Diane P.
United States, Seattle
University of Washington
Simoni, Jane M.
United States, Seattle
University of Washington
Hoff, P.
United States, Seattle
University of Washington
Matediana, Eduardo
Mozambique, Maputo
Ministry of Health Mozambique
Gloyd, Stephen S.
United States, Washington, D.c.
United States Department of Health and Human Services
Statistics
Citations: 25
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1080/09540120701203337
ISSN:
09540121
e-ISSN:
13600451
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Locations
Mozambique
Participants Gender
Male
Female