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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of the Effect on Outcomes of the Route of Administration of Corticosteroids in Acute Vogt-Koyanagi-Harada Disease
American Journal of Ophthalmology, Volume 142, No. 1, Year 2006
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Description
Purpose: To compare the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease. Design: Retrospective comparative interventional case series. Methods: settings: Nine international uveitis specialty clinics. study population: Forty-eight patients presenting over a three-year period to a study center with acute Vogt-Koyanagi-Harada disease. intervention: Initial treatment with corticosteroid either orally (Oral only group) or intravenously followed by an oral taper (IV+Oral group). main outcome measures: Change in visual acuity with treatment; development of ocular complications, including visually significant cataract, choroidal neovascularization, subretinal fibrosis, fundus pigment migration, nummular hypopigmented lesions, and diffuse fundus depigmentation; use of immunosuppressive therapy. Results: The Oral only group comprised 15 patients (31%) and the IV+Oral group 33 patients (69%). Median follow-up was 15 months. There was no difference in duration of follow-up between groups (P = .234). There was no difference in the change in visual acuity between groups, adjusting for initial visual acuity (P = .402). There were no differences in the rates of development of visually significant cataract, fundus pigmentary changes, or in the rate of use of subsequent immunosuppressive therapy between treatment groups. No patients developed choroidal neovascularization or subretinal fibrosis over the study period. Conclusions: Route of administration of corticosteroid had no detectable effect on change in visual acuity nor on the development of visually significant complications over the study period. Prospective trials are necessary to address speed of resolution and definitively answer outcome questions. © 2006 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Read, Russell W.
United States, Birmingham
The University of Alabama at Birmingham
Yu, Fei
United States, Los Angeles
Ucla Stein Eye Institute
Accorinti, Massimo
Italy, Rome
Sapienza Università Di Roma
Bodaghi, Bahram
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Chee, Soon Phaik
Singapore, Singapore City
Singapore National Eye Centre
Fardeau, Christine
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Goto, Hiroshi
Japan, Tokyo
Tokyo Medical University
Holland, Gary N.
United States, Los Angeles
Ucla Stein Eye Institute
Kawashima, Hidetoshi
Japan, Tokyo
The University of Tokyo
Kojima, Eri
Japan, Mitaka
Kyorin University Faculty of Medicine
LeHoang, Phuc
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Lemaitre, Claire
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Okada, Annabelle A.
Japan, Mitaka
Kyorin University Faculty of Medicine
Pivetti-Pezzi, Paola
Italy, Rome
Sapienza Università Di Roma
Secchi, Antonio
Italy, Padua
Università Degli Studi Di Padova
See, Robert F.
United States, Los Angeles
Doheny Eye Institute
Tabbara, Khalid F.
Saudi Arabia, Riyadh
The Eye Foundation for Research in Ophthalmology
Usui, Masahiko
Japan, Tokyo
Tokyo Medical University
Rao, Narsing A.
United States, Los Angeles
Doheny Eye Institute
Statistics
Citations: 96
Authors: 19
Affiliations: 11
Identifiers
Doi:
10.1016/j.ajo.2006.02.049
ISSN:
00029394
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study