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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Patients with activated B-cell like diffuse large B-cell lymphoma in high and low infectious disease areas have different inflammatory gene signatures
Leukemia and Lymphoma, Volume 54, No. 5, Year 2013
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Description
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with an association with inflammation and viral infections. We hypothesize that environmental factors may be involved in the pathogenesis of DLBCL. In this study, we compared gene expression profiles of lymph node tissues from patients with DLBCL from two different geographical areas with diverse environmental exposures. Specimens from Egyptian and Swedish patients with DLBCL as well as controls were studied. Gene expression analysis using microarray and quantitative polymerase chain reaction demonstrated significantly higher expression of signal transducer and activator of transcription 3 (STAT3) in Swedish as compared to Egyptian patients and control materials from both countries. This was confirmed at protein level using confocal microscopy. The receptor tyrosine kinase ROR1, a "survival factor" for malignant cells, was overexpressed and significantly related to the STAT3 expression pattern. The difference in the expression of genes involved in inflammatory responses and in the tumorigenic process of DLBCL might relate to infectious agents and/or other environmental exposures. © 2013 Informa UK, Ltd.
Authors & Co-Authors
Högfeldt, Therese
Sweden, Stockholm
Karolinska Universitetssjukhuset
Bahnassy, Abeer Ahmed
Egypt, Giza
National Cancer Institute
Kwiecinska, Anna
Sweden, Stockholm
Karolinska Universitetssjukhuset
Österborg, Anders C.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Tamm, Katja Pokrovskaja
Sweden, Stockholm
Karolinska Universitetssjukhuset
Porwit, Anna A.
Canada, Toronto
Toronto General Hospital
Zekri, Abdelrahman N.
Egypt, Giza
Cairo University
Lundahl, Joachim
Sweden, Stockholm
Karolinska Universitetssjukhuset
Khaled, Hussein Mostafa
Egypt, Giza
Cairo University
Mellstedt, Hȧkan T.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Moshfegh, Ali
Sweden, Stockholm
Karolinska Universitetssjukhuset
Statistics
Citations: 11
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.3109/10428194.2012.738365
ISSN:
10428194
e-ISSN:
10292403
Research Areas
Cancer
Genetics And Genomics
Study Approach
Quantitative