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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European study (EUSTAR)
Journal of Rheumatology, Volume 37, No. 8, Year 2010
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Description
Objective. To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. Methods. A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5′ allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3. Results. Neither FCGR2A 519A>G nor FCGR3A 559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement. Conclusion. Our study strongly suggests the lack of a role for the FCGR2A 519A>G and FCGR3A 559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts. The Journal of Rheumatology Copyright © 2010. All rights reserved.
Authors & Co-Authors
Alizadeh, Behrooz Z.
Netherlands, Utrecht
University Medical Center Utrecht
Hesselstrand, Roger
Sweden, Lund
Skånes Universitetssjukhus
Wuttge, Dirk Marcus
Sweden, Lund
Skånes Universitetssjukhus
Ortego-Centeno, Norberto
Unknown Affiliation
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Herrick, Ariane L.
United Kingdom, Salford
Salford Royal Nhs Foundation Trust
Denton, Christopher Paul
United Kingdom, London
Ucl Medical School
Riemekasten, Gabriela
Germany, Berlin
Charité – Universitätsmedizin Berlin
Vonk, Madelon C.
Netherlands, Nijmegen
Radboud University Medical Center
van den Hoogen, Frank H.J.
Netherlands, Nijmegen
St. Martin Clinic, Nijmegen
Guiducci, Serena
Unknown Affiliation
Matucci-Cerinić, Marco M.
Unknown Affiliation
Scorza, Raffaella
Italy, Milan
Università Degli Studi Di Milano
Beretta, Lorenzo
Italy, Milan
Università Degli Studi Di Milano
Airo’, Paolo
Italy, Brescia
Servizio Di Reumatologia e Immunologia Clinica
Coenen, Marieke J.H.
Netherlands, Nijmegen
Radboud University Medical Center
Martin, Javier
Unknown Affiliation
Koeleman, Bobby P.C.
Netherlands, Utrecht
University Medical Center Utrecht
Radstake, Timothy R.D.J.
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 11
Authors: 19
Affiliations: 12
Identifiers
Doi:
10.3899/jrheum.091259
ISSN:
0315162X
Research Areas
Genetics And Genomics
Study Design
Cohort Study