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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Chronic hepatitis c genotype-4 infection: Role of insulin resistance in hepatocellular carcinoma
Virology Journal, Volume 8, Article 496, Year 2011
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Description
Background: Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma (HCC) and different HCV genotypes show characteristic variations in their pathological properties. Insulin resistance (IR) occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV genotype-4 (HCV-4) on prevalence of insulin resistance in chronic hepatitis C (CHC) and HCC in Egyptian patients. Methods. Fifty CHC patients, 50 HCC patients and 20 normal subjects were studied. IR was estimated using HOMA-IR index and HCV-4 load determined using real-time polymerase chain reaction. Hepatitis B virus was excluded by enzyme-linked immunosorbent assay. Standard laboratory and histopathological investigations were undertaken to characterize liver function and for grading and staging of CHC; HCC staging was undertaken using intraoperative samples. Results: HCC patients showed higher IR frequency but without significant difference from CHC (52% vs 40%, p = 0.23). Multivariate logistic regression analysis showed HOMA-IR index and International Normalization Ratio independently associated with fibrosis in CHC; in HCC, HbA1c, cholesterol and bilirubin were independently associated with fibrosis. Fasting insulin and cholesterol levels were independently associated with obesity in both CHC and HCC groups. Moderate and high viral load was associated with high HOMA-IR in CHC and HCC (p < 0.001). Conclusions: IR is induced by HCV-4 irrespective of severity of liver disease. IR starts early in infection and facilitates progression of hepatic fibrosis and HCC development. © 2011 Mohamed et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Mohamed, Amal Ahmed
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Loutfy, Samah Aly
Egypt, Giza
Cairo University
Craik, James D.
Kuwait, Kuwait City
Kuwait University
Hashem, Abd Algawad M.
Egypt, Cairo
Faculty of Pharmacy
Siam, Ibrahem
Egypt, Giza
National Research Centre
Statistics
Citations: 35
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1186/1743-422X-8-496
e-ISSN:
1743422X
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Egypt