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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Correlation between sperm morphology, acrosin, and fertilization in an IVF program
Systems Biology in Reproductive Medicine, Volume 20, No. 3, Year 1988
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Description
Acrosin, a neutral proteinase, is located within the acrosome. The aim of this study was to evaluate acrosin concentrations in patients with severe damage of the sperm head and to determine whether acrosin concentration could predict the chances of fertilization in an IVF program. Sixty patients were accepted into this study, prospectively. The patients were divided into two groups, those with a normal morphology of < 14% (group I, n - 33) and those with normal morphology ± 14% (group II, n - 27). All the patients had a sperm concentration of >20 million sperm/ml and >30% progressively motile sperm. The acrosin assays were performed on the semen sample obtained on the day of IVF. Routine IVF insemination procedures were used, and only mature oocytes were considered. The only factor that showed a significant correlation with fertilization was normal morphology (p< 0.01). The mean acrosin level was 73.4 ± 38.6 mIU/10 million sperm in group I and 70.9 ± 42.7 mIU/10 million sperm in group II (no significant difference). The fertilization rate in group I was 45.4% and in group II, 77.7% p< 0.002). Acrosin levels were not significantly different in patients with and without fertilization (72.0 ± 42.1 and 73.6 ± 8.5 mIU/10 million sperm, respectively). © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Kruger, Thinus F.
United States, Norfolk
Eastern Virginia Medical School
Haque, D.
United States, Norfolk
Old Dominion University
Acosta, Aníbal A.
United States, Norfolk
Eastern Virginia Medical School
Pleban, Patricia A.
United States, Norfolk
Old Dominion University
Swanson, Robert James
United States, Norfolk
Old Dominion University
Simmons, Kathryn F.
United States, Norfolk
Old Dominion University
Matta, James F.
United States, Norfolk
Old Dominion University
Morshedi, Mahmood S.
United States, Norfolk
Old Dominion University
Oehninger, Sergio Carlos
United States, Norfolk
Eastern Virginia Medical School
South Africa, Stellenbosch
Stellenbosch University
Statistics
Citations: 36
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.3109/01485018808987078
ISSN:
19396376