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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis
Journal of Maternal-Fetal and Neonatal Medicine, Volume 22, No. 12, Year 2009
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Description
Objective. Aquaporin 9 (AQP9) is a water channel protein characterized by its high permeability to nutrients such as lactate and glycerol, as well as urea and other small solutes. These unique properties of AQP9 suggest that this molecule may play a role in the modulation of nutrient flux through the fetal membranes in conditions associated with increased metabolic demand, such as spontaneous labor and inflammation. The objective of this study was to determine the expression of AQP9 in the chorioamniotic membranes from women with and without term labor, as well as those with preterm prelabor rupture of membranes (PPROM) with and without histologic chorioamnionitis. Study design. A cross-sectional study was performed which included patients in the following groups: (1) term not in labor (TNL; n=14); (2) term, spontaneous labor (n=14); and (3) PPROM with (n20) and without (n=17) histologic chorioamnionitis. AQP9 mRNA expression in fetal membranes was quantified using quantitative real-time reverse transcription-polymerase chain reaction and analyzed with a linear model including gestational age as a covariate. Results. (1) AQP9 mRNA expression was identified in all chorioamniotic membrane specimens; (2) AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with TNL (fold change 3.6; p=0.01); and (3) Among patients with PPROM, the presence of histologic chorioamnionitis was associated with a higher expression of AQP9 in the chorioamniotic membranes compared with those from women without histologic chorioamnionitis (fold change 8.7; p<0.001). Conclusion. Aquaporin 9 mRNA expression is higher in the fetal membranes from patients with spontaneous term labor and those with PPROM and histologic chorioamnionitis. These findings are novel, and suggest a role for aquaporin 9 in membrane-mediated transfer of nutrients to support the increased metabolic demands associated with the host immune response of the terminal pathway of parturition and histologic chorioamnionitis. © 2009 Informa UK Ltd.
Authors & Co-Authors
Romero, Roberto J.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Detroit
Wayne State University
Tromp, Gerard C.
United States, Detroit
Wayne State University
Tarca, Adi Laurentiu
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Detroit
Wayne State University
Chaiworapongsa, Tinnakorn
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Erez, Offer
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Than, Nandor Gábor
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Hassan, Sonia S.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Statistics
Citations: 18
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.3109/14767050903019692
ISSN:
14764954
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Female