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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: Results of a single-center case-control study
Annals of Hematology, Volume 83, No. 11, Year 2004
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Description
No identifiable cause can be found in more than half of the cases of portal vein thrombosis (PVT). Our aim was to assess the prevalence of factor V Leiden mutation and other thrombophilic factors as risk factors in the development of PVT in the pediatric age group. From March 2001 to January 2002, 40 children with PVT were enrolled in the study, in addition to 20 age-matched and sex-matched controls. Protein C, protein S, antithrombin III, and activated protein C resistance (APCR) were assayed. Molecular study of factor II and factor V mutations was carried out. Of the patients, 25 had detectable hereditary thrombophilia (62.5%), 12 had factor V Leiden mutation (30%), 11 had protein C deficiency (27.5%), 6 had factor II mutation (15%), 1 had antithrombin III deficiency (2.5%), and none had protein S deficiency. Five children had concurrence of more than one defect. Factor V Leiden mutation is the most common hereditary thrombophilia associated with PVT and the relative risk of factor V Leiden mutation, as a cause of PVT, was six times more than in controls (odds ratio=6). Concurrence of more than one hereditary thrombophilic factor was seen in 12.5% of our patients. Circumstantial risk factors (neonatal sepsis, umbilical sepsis, umbilical catheterization) were not more significantly prevalent among patients with hereditary thrombophilia than among those with no detectable abnormalities in anticoagulation. © Springer-Verlag 2004.
Authors & Co-Authors
El Karaksy, H. M.
Egypt, Cairo
Faculty of Medicine
El-Koofy, Nehal Mohammad
Egypt, Cairo
Faculty of Medicine
El-Hawary, Manal
Egypt, Cairo
Faculty of Medicine
Ibrahim, Azza Mostafa
Egypt, Cairo
Faculty of Medicine
Aziz, Mona
Egypt, Cairo
Faculty of Medicine
El-Shabrawi, Mortada H.F.
Egypt, Cairo
Faculty of Medicine
Mohsen, Nabil Abd
Egypt, Cairo
Faculty of Medicine
Kotb, Magd Ahmed
Egypt, Cairo
Faculty of Medicine
El Raziky, Mona Said
Egypt, Cairo
Faculty of Medicine
El-Sonoon, Marwa Abu
Egypt, Cairo
Faculty of Medicine
A-Kader, H. H.
United States, Tucson
The University of Arizona
Statistics
Citations: 55
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1007/s00277-004-0921-4
ISSN:
09395555
Research Areas
Cancer
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study