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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Consanguinity associated with increased risk for bipolar I disorder in Egypt
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Volume 150, No. 6, Year 2009
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Description
We aimed to contrast rates of consanguinity among patients with bipolar I disorder (BP1) and controls in a population with customary consanguineous marriages (i.e., marriage between related individuals). Consanguinity increases risk for numerous monogenic and polygenic diseases. Whether the risk for BP1 increases with consanguinity has not been investigated systematically. Two independent studies were conducted in Egypt: (1) Case-control study 93 patients with BP1, 90 screened adult control individuals, and available parents. The inbreeding coefficient/consanguinity rate was estimated in two ways: using 64 DNA polymorphisms ("DNA-based" rate); and from family history data ("self report"); (2) Epidemiological survey: total of 1,584 individuals were screened, from whom self-reported consanguinity data were obtained for identified BP1 cases (n = 35) and 150 randomly selected, unaffected control individuals. DNA-based consanguinity rates showed significant case-control control differences (P = 0.0039). Self-reported consanguinity rates were also elevated among BP1 patients in both samples (Study #1 OR = 2.66, 95% confidence intervals, CI: 1.34, 5.29; Study #2: OR = 4.64, 95% CI: 2.01, 10.34). In conclusion, two independent, systematic studies indicate increased consanguinity among Egyptian BP1 patients in the Nile delta region. Self-reported estimates of consanguinity are bolstered by DNA-based estimates, and both show significant case-control differences for BP1. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Mansour, Hader A.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Egypt, Mansoura
Faculty of Medicine
Klei, Lambertus
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Wood, Joel A.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Talkowski, Michael E.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Chowdari, Kodavali Venkat
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Fathi, Warda
Egypt, Mansoura
Faculty of Medicine
Eissa, Ahmed Ibrahim
Egypt, Mansoura
Faculty of Medicine
Yassin, Amal
Egypt, Mansoura
Faculty of Medicine
Salah, Hala
Egypt, Mansoura
Faculty of Medicine
Tobar, Salwa Salah
Egypt, Mansoura
Faculty of Medicine
El-Boraie, Hala Ahmed
Egypt, Mansoura
Faculty of Medicine
Gaafar, Hanan
Egypt, Mansoura
Faculty of Medicine
Elassy, Mai
Egypt, Mansoura
Faculty of Medicine
Ibrahim, Nahed E.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
El-Bahaei, Wafaa
Egypt, Mansoura
Faculty of Medicine
Elsayed, Mohamed Abd Elaziz
Egypt, Mansoura
Faculty of Medicine
Shahda, Mohamed
Egypt, Mansoura
Faculty of Medicine
El-Sheshtawy, Eman Abdel Moty
Egypt, Mansoura
Faculty of Medicine
El-Boraie, Osama A.
Egypt, Mansoura
Faculty of Medicine
El-Chennawi, Farha Abdel Aziz
Egypt, Mansoura
Faculty of Medicine
Devlin, Bernie
United States, Pittsburgh
Upmc Western Psychiatric Hospital
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Nimgaonkar, Vishwajit Laxmikant
United States, Pittsburgh
Upmc Western Psychiatric Hospital
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Statistics
Citations: 30
Authors: 22
Affiliations: 3
Identifiers
Doi:
10.1002/ajmg.b.30913
ISSN:
15524841
e-ISSN:
1552485X
Research Areas
Genetics And Genomics
Mental Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Egypt