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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa
Vaccine, Volume 26, No. 22, Year 2008
Notification
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Description
The safety and immunogenicity of plasmid pTHr DNA, modified vaccinia virus Ankara (MVA) human immunodeficiency virus type 1 (HIV-1) vaccine candidates were evaluated in four Phase I clinical trials in Kenya and Uganda. Both vaccines, expressing HIV-1 subtype A gag p24/p17 and a string of CD8 T-cell epitopes (HIVA), were generally safe and well-tolerated. At the dosage levels and intervals tested, the percentage of vaccine recipients with HIV-1-specific cell-mediated immune responses, assessed by a validated ex vivo interferon gamma (IFN-γ) ELISPOT assay and Cytokine Flow Cytometry (CFC), did not significantly differ from placebo recipients. These trials demonstrated the feasibility of conducting high-quality Phase 1 trials in Africa. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Jaoko, Walter G.
Kenya, Nairobi
University of Nairobi
Nakwagala, Frederick Nelson
Uganda, Entebbe
Uganda Virus Research Institute
Anzala, Aggrey Omu
Kenya, Nairobi
University of Nairobi
Manyonyi, Gloria Omosa
Kenya, Nairobi
University of Nairobi
Birungi, Josephine
Uganda, Entebbe
Uganda Virus Research Institute
Nanvubya, Annet
Uganda, Entebbe
Uganda Virus Research Institute
Bashir, Farah
Kenya, Nairobi
University of Nairobi
Bhatt, Kirana M.
Kenya, Nairobi
University of Nairobi
Ogutu, Hilda
Kenya, Nairobi
University of Nairobi
Wakasiaka, Sabina N.
Kenya, Nairobi
University of Nairobi
Matu, Lucy
Kenya, Nairobi
University of Nairobi
Waruingi, Wambui
Kenya, Nairobi
University of Nairobi
Odada, Jane
Kenya, Nairobi
University of Nairobi
Oyaro, Micah Ongeri
Kenya, Nairobi
University of Nairobi
Indangasi, Jackton
Kenya, Nairobi
University of Nairobi
Ndinya-Achola, Jeckoniah O.
Kenya, Nairobi
University of Nairobi
Konde, Carol
Uganda, Entebbe
Uganda Virus Research Institute
Mugisha, Emmanuel
Uganda, Entebbe
Uganda Virus Research Institute
Fast, Patricia E.
United States, New York
International Aids Vaccine Initiative
Schmidt, Claudia
United States, New York
International Aids Vaccine Initiative
Gilmour, Jill W.
United Kingdom, London
Imperial College London
Tarragona, Tony
United Kingdom, London
Imperial College London
Smith, Carol M.
United States, Rockville
The Emmes Corporation
Barin, Burc
United States, Rockville
The Emmes Corporation
Dally, Len G.
United States, Rockville
The Emmes Corporation
Johnson, Bruce
United States, New York
International Aids Vaccine Initiative
Muluubya, Andrew
Uganda, Entebbe
Uganda Virus Research Institute
Nielsen, Leslie Elizabeth
United States, New York
International Aids Vaccine Initiative
Hayes, Peter John
United Kingdom, London
Imperial College London
Boaz, Mark J.
United Kingdom, London
Imperial College London
Hughes, Peter
Uganda, Entebbe
Uganda Virus Research Institute
Hanke, T.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
McMichael, Andrew James
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Kaleebu, Pontiano P.
Uganda, Entebbe
Uganda Virus Research Institute
Statistics
Citations: 97
Authors: 35
Affiliations: 6
Identifiers
Doi:
10.1016/j.vaccine.2008.02.071
ISSN:
0264410X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Kenya
Uganda