Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry
Drugs, Volume 81, No. 6, Year 2021
Notification
URL copied to clipboard!
Description
Background: The impact of statins on COVID-19 outcomes is important given the high prevalence of their use among individuals at risk for severe COVID-19. Our aim is to assess whether patients receiving chronic statin treatment who are hospitalized with COVID-19 have reduced in-hospital mortality if statin therapy is maintained during hospitalization. Methods: This work is a cross-sectional, observational, retrospective multicenter study that analyzed 2921 patients who required hospital admission at 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics and COVID-19 disease outcomes between patients receiving chronic statin therapy who maintained this therapy during hospitalization versus those who did not. Propensity score matching was used to match each statin user whose therapy was maintained during hospitalization to a statin user whose therapy was withdrawn during hospitalization. Results: After propensity score matching, continuation of statin therapy was associated with lower all-cause mortality (OR 0.67, 0.54–0.83, p < 0.001); lower incidence of acute kidney injury (AKI) (OR 0.76,0.6–0.97, p = 0.025), acute respiratory distress syndrome (ARDS) (OR 0.78, 0.69- 0.89, p < 0.001), and sepsis (4.82% vs 9.85%, p = 0.008); and less need for invasive mechanical ventilation (IMV) (5.35% vs 8.57, p < 0.001) compared to patients whose statin therapy was withdrawn during hospitalization. Conclusions: Patients previously treated with statins who are hospitalized for COVID-19 and maintain statin therapy during hospitalization have a lower mortality rate than those in whom therapy is withdrawn. In addition, statin therapy was associated with a decreased probability that patients with COVID-19 will develop AKI, ARDS, or sepsis and decreases the need for IMV. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Authors & Co-Authors
González García, A.
Spain, Madrid
Hospital Universitario Ramón y Cajal
Ramos-Rincón, José Manuel
Spain, Elche
Universidad Miguel Hernández de Elche
Gómez-Huelgas, Ricardo
Spain, Malaga
Universidad de Málaga
Lumbreras, Carlos
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
De-Miguel-Campo, Borja
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Lora-Tamayo, Jaime
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Maestro-de la Calle, Guillermo
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Fernández, Marcos Sánchez
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Homs, Narcís A.
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Calvo, Cristina Marcelo
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Robles, Elena Martínez
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Cómet, Luis Sáez
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Estrada, Vicente P.
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Méndez-Bailón, Manuel
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Muñoz, Anna Maria Alguacil
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Galán, Pilar Redondo
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Martínez, Luis
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Cervera, Carlos García
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Wikman-Jorgensen, Philip Erik
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Fernàndez, Javier C.
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Vazquez, M. J.
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Luque, Francisco Javier
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Villar, Jesús Manuel Fernández
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Statistics
Citations: 35
Authors: 23
Affiliations: 14
Identifiers
Doi:
10.1007/s40265-021-01498-x
ISSN:
00126667
Research Areas
Covid
Health System And Policy
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study