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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Significant association between interleukin-17A polymorphism and colorectal cancer
Tumor Biology, Volume 35, No. 7, Year 2014
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Description
Interleukin (IL) 17A is an inflammatory cytokine expressed by Th 17 cells and plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We have investigated the association between colorectal cancer and polymorphisms of IL17A (rs2275913. G197A). The study was performed in 241 subjects (102 with colorectal cancer and 139 healthy controls). Genotypes were determined by fluorescent-based restriction fragment length polymorphism method. The association between the molecular features at the gene in relation to tumor and patient clinical characteristics was analyzed. There was a significant difference between the genotype frequencies of IL17A G197A of control subjects (GG 68.34 % and GA + AA 31.65 %) and patients with colorectal cancer (GG 47.05 % and GA + AA 52.94 %) (p=0.001with odds ratio (OR) 2.45 (1.43-4.11)). IL17A G197A polymorphism is particularly associated with colon cancer. Indeed, the IL17A GG genotype could be considered as a protective factor against colon cancer (p=0.00001) with OR 3.77 (2.04-6.99). We have noted a significant association of IL17A G197A polymorphism not only with tumor localization (p=0.003) but also with tumor differentiation (p=0.0005) in CRC patients. We have also showed a significant association of G197A variant with an increased risk of advanced stage (p=0.005). Our result suggests that the A allele of IL17A gene is involved in susceptibility to colorectal cancer and is associated with clinical features as tumor location, tumor differentiation, and TNM stage. IL17A polymorphism may serve as biomarker of disease location and progression. © 2014 International Society of Oncology and BioMarkers (ISOBM).
Authors & Co-Authors
Ben Omrane, Inés
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Marrakchi, R.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Baroudi, Olfa
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Mézlini, Amel
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Ayari, Hager
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Medimegh, Imen
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Stambouli, Nejla
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Kourda, Nadia
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Bouzaienne, Hassen
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Uhrhammer, Nancy A.
France, Clermont-ferrand
Centre Jean Perrin
Bougatef, Karim
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Bignon, Yves Jean
France, Clermont-ferrand
Centre Jean Perrin
Benammar-Elgaaïed, Amel
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Statistics
Citations: 42
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1007/s13277-014-1890-4
ISSN:
10104283
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Case-Control Study