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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Differences in risk-factor profiles between patients with ESBL-producing Escherichia coli and Klebsiella pneumoniae: A multicentre case-case comparison study
Antimicrobial Resistance and Infection Control, Volume 3, No. 1, Article 27, Year 2014
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Description
Background: Generic epidemiological differences between extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP), are poorly defined. Nonetheless, defining such differences and understanding their basis could have strategic implications for infection control policy and practice.Methods: Between 2009 and 2011 patients with bacteraemia due to ESBL-EC or ESBL-KP across all three acute hospitals in the city of Auckland, New Zealand, were eligible for inclusion. Recognised risk factors for ESBL bacteraemia were compared between species in a retrospective case-case study design using multivariate logistic regression. Representative isolates underwent ESBL gene characterisation and molecular typing.Results: 170 patients and 176 isolates were included in the study (92 patients with ESBL-EC, 78 with ESBL-KP). 92.6% had CTX-Ms. 39% of EC were ST131 while 51% of KP belonged to 3 different STs (i.e. ST20, ST48 & ST1087). Specific sequence types were associated with specific hospitals for ESBL-KP but not ESBL-EC. Variables positively associated with ESBL-EC on multivariate analysis were: community acquired infection (odds ratio [OR] 7.9; 95% CI: 2.6-23.9); chronic pulmonary disease (OR 5.5; 95% CI: 1.5-20.1); and high prevalence country of origin (OR 4.3; 95% CI: 1.6-11.6). Variables negatively associated with ESBL-EC were previous transplant (OR 0.06; 95% CI: 0.007-0.6); Hospital 2 (OR 0.3; 95% CI: 0.1-0.7) and recent ICU admission (OR 0.3; 95% CI: 0.07-0.9).Conclusions: Differences in risk profiles between patients with ESBL-EC and ESBL-KP suggest fundamental differences in transmission dynamics. Understanding the biological basis for these differences could have implications for infection control practice. Tailoring of infection control measures according to ESBL species may be indicated in some instances. © 2014 Freeman et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Rubin, Joseph E.
Canada, Calgary
Calgary Laboratory Services
McAuliffe, Gary N.
New Zealand, Auckland
Auckland District Health Board
Peirano, Gisele
Canada, Calgary
Calgary Laboratory Services
Roberts, Sally A.
New Zealand, Auckland
Auckland District Health Board
New Zealand, Auckland
The University of Auckland
Drinković, Dragana
New Zealand, North Shore City
Waitemata District Health Board
Pitout, Johann D.D.
Canada, Calgary
Calgary Laboratory Services
Statistics
Citations: 26
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1186/2047-2994-3-27
ISSN:
20472994
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Case Study
Study Approach
Qualitative