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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The diagnosis of typhoid fever in the Democratic Republic of the Congo
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, No. 6, Year 2012
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Description
The diagnosis of typhoid fever (TF) in Kinshasa (DR Congo) was assessed by on-site surveys, external quality assessment (EQA) of the Widal test and a microbiological blood culture surveillance study. In 331/536 (61.8%) health facilities, clinicians diagnosed TF by clinical picture and the Widal test. An EQA on the Widal test consisting of three samples revealed correct scores by respectively 27.1%, 65.6% and 3.1% of 125 participating laboratories. Most (80.9% of 152 laboratories) performed <100 Widal tests per month, with a median sample positivity rate of 32.6% (range 0-90.7%). The Widal test was mostly performed on a single sample and by slide agglutination (89.5% and 97.0% respectively); errors in cold chain and procedures were recorded (not making serial dilutions, estimating titres by the intensity of agglutination). Among 293 prescribers, 52.2% and 40.8% requested the Widal test for treatment follow-up and detection of chronic carriers respectively. Salmonella Typhi was recovered from the blood in 2.4% of 3820 patients suspected as having TF, with non-typhoid Salmonellae and other Enterobacteriaceae accounting for the majority of organisms. In conclusion, clinicians rely highly on the Widal test for the diagnosis of TF and the Widal test is poorly performed and interpreted. © 2012 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Lunguya, Octavie
Democratic Republic Congo, Kinshasha
National Institute for Biomedical Research
Democratic Republic Congo
University Hospital of Kinshasa
Phoba, Marie France
Democratic Republic Congo, Kinshasha
National Institute for Biomedical Research
Democratic Republic Congo
University Hospital of Kinshasa
Ahuka-Mundeke, Steve
Democratic Republic Congo, Kinshasha
National Institute for Biomedical Research
Democratic Republic Congo
University Hospital of Kinshasa
Bonebe, Edmonde
Democratic Republic Congo, Kinshasha
National Institute for Biomedical Research
Mukadi, Pierre
Democratic Republic Congo, Kinshasha
National Institute for Biomedical Research
Muyembe-Tamfum, Jean Jacques
Democratic Republic Congo, Kinshasha
National Institute for Biomedical Research
Democratic Republic Congo
University Hospital of Kinshasa
Verhaegen, Jan L.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Jacobs, Jan Adriaan
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 33
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.trstmh.2012.03.006
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Study Locations
Congo