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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Diagnostic accuracy of urine filtration and dipstick tests for Schistosoma haematobium infection in a lightly infected population of Ghanaian schoolchildren
Acta Tropica, Volume 118, No. 2, Year 2011
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Description
Two screening methods, reagent dipsticks for hematuria and urine filtration for Schistosoma haematobium eggs, were evaluated for their sensitivity and specificity in diagnosing infection with S. haematobium in lightly infected Ghanaian children. Schoolchildren aged 8-18 years (n=255) provided urine samples on three occasions. Overall, 36.4% of girls and 50.7% of boys presented with eggs at least once; 3.3% of girls and 7.5% of boys presented with both eggs and hematuria three times. Many children presented with eggs but without hematuria, or with hematuria but without eggs. When each child was screened three times, the sensitivity of each test method improved by at least 22.9% as compared with single screening, but previously unidentified infections were detected at the third screening, indicating that even three screenings is insufficient. Nearly half of lightly infected children (<50 eggs/10. ml urine, by maximum egg count) were egg-positive during only one of three screenings. Thus, data presented here indicate that when individuals are screened repeatedly, infection status can be assessed more accurately, control programs can be properly evaluated, and population estimates of S. haematobium infection may be made with increased confidence, as compared with single screening. © 2011 Elsevier B.V.
Authors & Co-Authors
Kosinski, Karen Claire
United States, Medford
Tufts University
Bosompem, Kwabena Mante
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Stadecker, Miguel J.
United States, Boston
Tufts University School of Medicine
Wagner, Anjuli Dawn
United States, Medford
Tufts University
United States, Seattle
University of Washington
Plummer, Jeanine
United States, Worcester
Worcester Polytechnic Institute
Durant, John L.
United States, Medford
Tufts University
Gute, David M.
United States, Medford
Tufts University
Statistics
Citations: 49
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.actatropica.2011.02.006
ISSN:
0001706X
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Participants Gender
Male
Female