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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Differential acquisition of human antibody responses to Plasmodium falciparum according to intensity of exposure to Anopheles bites
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 106, No. 8, Year 2012
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Description
Malaria immunity is modulated by many environmental and epidemiological factors. This study evaluates the influence of a hitherto unstudied environmental-epidemiological factor, namely the impact of human exposure to Anopheles bites on the isotype profile of acquired antibody responses to Plasmodium falciparum. In two Senegalese villages where the intensity of exposure to Anopheles bites was markedly different (high and low exposure), specific IgG1 and IgG3 responses to P. falciparum whole schizont extract (WSE) and circumsporozoite protein (CSP) were evaluated at the peak of Anopheles exposure (September) and later (December) in a cohort of 120 children aged 3-8 years. Multivariate analysis showed a significantly lower IgG1 response against P. falciparum WSE and CSP in children highly exposed to Anopheles bites (Gankette) compared to those who were weakly exposed (Mboula). In contrast, in both villages, parasitemia and increasing age were strongly associated with higher IgG1 and IgG3 levels. We hypothesize that high exposure to Anopheles bites could inhibit IgG1-dependent responsiveness to P. falciparum known to induce protective immune responses against malaria. The impact of mosquito saliva on the regulation of specific protective immunity may need to be taken into account in epidemiological studies and trials for malaria vaccines. © 2012 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Sarr, Jean B.
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Samb, Badara
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sagna, André Barembaye
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Fortin, Sonia
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Doucouré, Souleymane
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Sow, Cheikh Saya
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Senghor, Simon
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Gaayeb, Lobna
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Paris
Inserm
Guindo, Soihibou
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Schacht, Anne Marie
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Paris
Inserm
Rogerie, François
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Hermann, Emmanuel
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Paris
Inserm
France, Lille
Université de Lille
Dia, Ibrahima K.
Senegal, Dakar
Institut Pasteur de Dakar
Konaté, Lassana
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Riveau, Gilles J.
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Paris
Inserm
Remoué, Franck J.
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Statistics
Citations: 16
Authors: 16
Affiliations: 6
Identifiers
Doi:
10.1016/j.trstmh.2012.05.006
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study