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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Acantholactam and pre- neo -kauluamine, manzamine-related alkaloids from the indonesian marine sponge Acanthostrongylophora ingens
Journal of Natural Products, Volume 77, No. 6, Year 2014
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Description
Two new manzamine alkaloids, acantholactam (3) and pre-neo-kauluamine (4), were isolated from the marine sponge Acanthostrongylophora ingens along with manzamine A (1) and neo-kauluamine (2). Acantholactam contains a γ-lactam ring N-substituted with a (Z)-2-hexenoic acid moiety and is proposed to be biosynthetically derived from manzamine A by oxidative cleavage of the eight-membered ring. Compound 4 was converted to the dimer 2 during storage, suggesting nonenzymatic dimer formation. Among the four isolated compounds, 1, 2, and 4 showed proteasome inhibitory activity. © 2014 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
El-Desoky, Ahmed H.
Japan, Kumamoto
Kumamoto University
Kato, Hikaru
Japan, Kumamoto
Kumamoto University
Eguchi, Keisuke
Japan, Kumamoto
Kumamoto University
Fujiwara, Yukio
Japan, Kumamoto
Kumamoto University
Losung, Fitje
Indonesia, Manado
Universitas Sam Ratulangi
Mangindaan, Remy E.P.
Indonesia, Manado
Universitas Sam Ratulangi
de Voogd, Nicole Joy D.E.
Netherlands, Leiden
Naturalis Biodiversity Center
Takeya, Motohiro
Japan, Kumamoto
Kumamoto University
Tsukamoto, Sachiko
Japan, Kumamoto
Kumamoto University
Statistics
Citations: 28
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1021/np500290a
ISSN:
01633864