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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic susceptibility to visceral leishmaniasis in The Sudan: Linkage and association with IL4 and IFNGR1
Genes and Immunity, Volume 4, No. 5, Year 2003
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Description
Longitudinal studies in Sudan show ethnic differences in incidence and clinical phenotypes associated with Leishmania donovani. Immunologically, bias in type 1 vs type 2 cytokine responses is important. To determine whether polymorphisms at IL4/IL9 or IFNGR1 contribute to susceptibility, we examined 59 multicase families of visceral leishmaniasis (VL) with/without post Kala-azar dermal leishmaniasis (PKDL). Multipoint nonparametric analysis (Allegro) linked IL4/IL9 to VL per se (P = 0.002). Transmission disequilibrium testing with robust variance estimates confirmed association in the presence of linkage between VL per se and IL4 (P = 0.008) but not IL9. Stepwise logistic regression analysis showed both IL4RP2 and IL4RP1 markers contributed significantly to the association, suggesting a common disease-associated haplotype. In contrast, IFNGR1 was linked (P = 0.031) and associated (P = 0.007) to PKDL but not VL or VL per se. Hence, polymorphism in a type 2 cytokine gene influences underlying susceptibility to VL, whereas IFNGR1 is specifically related to susceptibility to PKDL. © 2003 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Mohamed, H. S.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
United Kingdom, Cambridge
Addenbrooke's Hospital
Ibrahim, Muntaser Eltayeb
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Miller, Elinor Nancy
United Kingdom, Cambridge
Addenbrooke's Hospital
Peacock, Christopher Sean
United Kingdom, Cambridge
Addenbrooke's Hospital
Khalil, Eltahir Awad Gasim
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Cordell, Heather Jane
United Kingdom, Cambridge
Addenbrooke's Hospital
el-Hassan, Ahmed Mohamed A.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Bereir, Rihab E H
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Blackwell, Jenefer Mary
United Kingdom, Cambridge
Addenbrooke's Hospital
Statistics
Citations: 93
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1038/sj.gene.6363977
ISSN:
14664879
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Sudan