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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immune depression in trypanosome‐infected mice. II. Characterization of the spleen cell types involved
European Journal of Immunology, Volume 9, No. 3, Year 1979
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Description
Spleen cells from Trypanosoma congolense‐infected mice showed a drastic depression in their capacity to respond to B and T lymphocyte mitogens and to allogeneic spleen cells in mixed lymphocyte cultures. Spleen cells from infected mice were also poor stimulators in mixed lymphocyte cultures. The poor responsiveness or stimulation capacity was not due simply to dilution of relevant B or T lymphocytes by the large number of null cells found in the spleens of infected animals. These null cells expressed approximately eight times more H‐2 antigen than spleen cells from normal (uninfected) mice and were devoid of Ia antigens. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Authors & Co-Authors
Roelants, Georges E.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Pearson, Terry W.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Mayor-Withey, Kathleen S.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Lundin, Lena B.
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Tyrer, Harry W.
United States, Research Triangle Park
Dickinson and Company
Statistics
Citations: 13
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1002/eji.1830090305
e-ISSN:
15214141
Research Areas
Mental Health