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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The cytokine balance during CABG surgery with and without cardiopulmonary bypass
Egyptian Journal of Anaesthesia, Volume 26, No. 4, Year 2010
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Description
Background: We investigated the cytokine response during coronary artery bypass grafting (CABG) surgery with and without cardiopulmonary bypass (off-pump) and the effect on patient's outcome in the early postoperative period. Methods: Eighteen patients were studied, 9 patients undergoing off-pump surgery (group 1) and 9 patients with CPB (group 2). Demographic and preoperative characteristics were comparable in both groups. Plasma levels of TNF-α, IL-6, IL-8, IL-10, IL-4, tumour necrosis soluble receptors-1 (TNFsr-1) and tumour necrosis soluble receptors-2 (TNFsr-2) were measured before skin incision (T0), before revascularization (T1), after revascularization (T2), 2 h (T3) and 24 (T4) hours after skin closure. Levels of myocardial enzymes were also measured in the first postoperative morning. Results: Serum levels of TNF-α and IL-8 increased in group 2 at T3 and T4 more than at T0 (p < 0.05). IL-6 increased in both groups with higher levels in group 2 than in group 1 at T3 (773 ± 331 vs 315 ± 189 pg/ml; p < 0.05). IL-10 was higher in group 2 than in group 1 at T2 (115 ± 119 vs 13 ± 4 pg/ml; p < 0.001) and at T3 (212 ± 171 vs 31 ± 29 pg/ml; p < 0.05). At T3 levels of TNFsr-1 and TNFsr-2 were higher in group 2 than in group 1 (TNFsr-1 4858 ± 1325 vs 2089 ± 584 pg/ml; p < 0.01 and TNFsr-2 4971 ± 63 vs 3801 ± 738 pg/ml; p < 0.05). Production of IL-4 did not increase in neither group. The length of ICU stay was less in group 1 than in group 2 (52 ± 33 vs 26 ± 11 h; p < 0.05) as well as was the length of hospital stay (7.1 ± 0.4 vs 5.3 ± 0.5 days; p < 0.001). Conclusion: Off-pump procedure evoked a lower cytokine response than CABG with CPB. This minimised myocardial damage and shorten the stay in the ICU and the hospital. © 2010 Egyptian Society of Anesthesiologists. Production and hosting by Elsevier B.V. All rights reserved.
Authors & Co-Authors
El Azab, Samia R.
Saudi Arabia, Buraidah
King Fahd Specialist Hospital
Egypt, Cairo
Al-azhar University
Doha, Nagwa M.
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Rady, Ayman
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
El-Sayed, Abeer E.
Egypt, Ismailia
Faculty of Medicine
Abd-Rabo, Mahmoud
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Statistics
Citations: 5
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/j.egja.2010.05.003
ISSN:
11101849
e-ISSN:
16871804
Research Areas
Cancer
Health System And Policy