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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Nature Genetics, Volume 40, No. 2, Year 2008
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Description
Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 × 10-12) and intracranial aneurysm (OR = 1.29, P = 2.5 × 10-6), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases. © 2008 Nature Publishing Group.
Authors & Co-Authors
Helgadóttir, Anna
Iceland, Reykjavik
Decode Genetics
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Grétarsdóttir, Sólveig
Iceland, Reykjavik
Decode Genetics
Steinthórsdóttir, Valgerdur
Iceland, Reykjavik
Decode Genetics
Manolescu, Andrei
Iceland, Reykjavik
Decode Genetics
Jones, Gregory Thomas
New Zealand, Dunedin
Otago Medical School
Blankensteijn, J. D.
Netherlands, Nijmegen
Radboud University Medical Center
Ronkainen, Antti
Finland, Kuopio
Kuopio University Hospital
Jääskeläinen, Juha Erik
Finland, Kuopio
Kuopio University Hospital
Lenk, Guy M.
United States, Detroit
Wayne State University
Sakalihasan, Natzi
Belgium, Liege
Centre Hospitalier Universitaire de Liege
Kostulas, Konstantinos
Sweden, Stockholm
Karolinska Institutet
Stefánsson, Hreinn
Iceland, Reykjavik
Decode Genetics
Hansen, Torben Frøstrup
Denmark, Herlev
Steno Diabetes Center Copenhagen
Borch-Johnsen, Knut
Denmark, Herlev
Steno Diabetes Center Copenhagen
Denmark, Aarhus
Aarhus Universitet
Denmark, Glostrup
Amtssygehuset I Glostrup
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Shah, Svati H.
United States, Durham
Duke University
Erdmann, Jeanette Ali
United States, Atlanta
Emory University School of Medicine
Granger, Christopher B.
United States, Durham
Duke University
Reilly, Muredach P.
United States, Philadelphia
University of Pennsylvania
Levey, Aĺlan I.
United States, Atlanta
Emory University School of Medicine
Walters, G. Bragi
Iceland, Reykjavik
Decode Genetics
Ferrell, Robert E.
United States, Pittsburgh
University of Pittsburgh
Sveinbjörnsdóttir, Sigurlaug
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Niemelä, Mika R.
Finland, Helsinki
Helsinki University Hospital
Andersen, Karl K.
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Benediktsson, Rafn
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Kopavogur
Icelandic Heart Association
Teijink, Joep A.W.
Unknown Affiliation
Grobbee, Diederick E Egbertus
Netherlands, Utrecht
University Medical Center Utrecht
Rader, Daniel J.
United States, Philadelphia
University of Pennsylvania
Collier, David Andrew
United Kingdom, London
King's College London
Pedersen, Oluf Borbye
Denmark, Herlev
Steno Diabetes Center Copenhagen
Denmark, Aarhus
Aarhus Universitet
Pola, Roberto
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Hillert, Jan A.
Sweden, Stockholm
Karolinska Institutet
Lindblad, Bengt L.T.
Sweden, Lund
Skånes Universitetssjukhus
Valdimarsson, Einar Már
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Magnadóttir, Hulda Bra
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Wijmenga, Cisca
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Netherlands, Utrecht
University Medical Center Utrecht
Tromp, Gerard C.
United States, Detroit
Wayne State University
Baas, Annette F.
Netherlands, Utrecht
University Medical Center Utrecht
Ruigrok, Ynte Marije
Netherlands, Utrecht
University Medical Center Utrecht
van Rij, Andrè M.
New Zealand, Dunedin
Otago Medical School
Kuivaniemi, Helena
United States, Detroit
Wayne State University
Powell, Janet Tinka
United Kingdom, London
Imperial College London
Matthíasson, Stefán E.
Iceland, Reykjavik
Haskoli Islands
Gulcher, Jeffrey Robert
Iceland, Reykjavik
Decode Genetics
Thorgeirsson, Gudmundur
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Reykjavik
Haskoli Islands
Kong, Augustine
Iceland, Reykjavik
Decode Genetics
Thorsteinsdottir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Statistics
Citations: 617
Authors: 50
Affiliations: 25
Identifiers
Doi:
10.1038/ng.72
ISSN:
15461718
Research Areas
Noncommunicable Diseases
Study Design
Case-Control Study