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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
MR imaging in Duchenne muscular dystrophy: Quantification of T 1-weighted signal, contrast uptake, and the effects of exercise
Journal of Magnetic Resonance Imaging, Volume 30, No. 5, Year 2009
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Description
Purpose: To quantify the differences between normal and corticosteroid-treated Duchenne muscular dystrophy (DMD) lower limb muscle using signal intensity measurements on T1-weighted and gadolinium contrast-enhanced images and by measurement of muscle T2 values, and to investigate the effect of exercise. Materials and Methods: Eleven ambulant boys with DMD were imaged at 3 Tesla (T1-weighted, gadolinium enhancement and T2 measurement) before stepping exercise and again (gadolinium, T2 measurement) 4 days later and were compared with five healthy controls imaged 4 days before and after stepping exercise. Muscle region-of-interest signal intensities were referenced to external oil and gadolinium phantoms. Results: DMD thigh muscle T2 values were significantly higher than normal values with the exception of the gracilis muscle. Eight of nine muscles studied showed a significant increase in T 1-w signal intensity in DMD as compared to normal muscle, suggestive of increased fat infiltration in DMD muscle. In the DMD boys, an exercise effect (increased contrast enhancement) was only seen for the tibialis anterior muscle. Conclusion: Referenced signal intensity measurements may be used to quantify differences between dystrophic and normal muscle without T1 mapping. Stepping exercise does not have a large impact on subsequent MR imaging of dystrophic muscle. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Hollingsworth, Kieren Grant
United Kingdom, Newcastle
Newcastle University
Eagle, Michelle
United Kingdom, Newcastle
International Centre for Life
Aribisala, Benjamin Segun
United Kingdom, Newcastle
Newcastle University
Birchall, Daniel
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Bushby, Kate M.D.
United Kingdom, Newcastle
International Centre for Life
Straub, V. W.
United Kingdom, Newcastle
International Centre for Life
Statistics
Citations: 65
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1002/jmri.21941
ISSN:
15222586
Research Areas
Disability
Participants Gender
Male