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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of acute nicotine abstinence on cue-elicited ventral striatum/nucleus accumbens activation in female cigarette smokers: A functional magnetic resonance imaging study
Brain Imaging and Behavior, Volume 1, No. 3-4, Year 2007
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Description
To achieve greater understanding of the brain mechanisms underlying nicotine craving in female smokers, we examined the influence of nicotine non-abstinence vs. acute nicotine abstinence on cue-elicited activation of the ventral striatum. Eight female smokers underwent an event-related functional magnetic resonance imaging (fMRI) paradigm presenting randomized sequences of smoking-related and non-smoking related pictures. Participants were asked to indicate by a key press the gender of individuals in smoking-related and non-smoking related pictures (gender discrimination task), to maintain and evaluate attention to the pictures. There was a significant effect of smoking condition on reaction times (RT) for a gender discrimination task intended to assess and maintain attention to the photographs-suggesting a deprivation effect of acute nicotine abstinence and a statistical trend indicating greater RTs for smoking cues than neutral cues. BOLD contrast (smoking vs. non-smoking cues) was greater in the non-abstinent vs. acutely abstinent conditions in the ventral striatum including the nucleus accumbens (VS/NAc). Moreover, a significant positive correlation was observed between baseline cigarette craving prior to scanning and VS/NAc activation (r = 0.84, p = 0.009), but only in the non-abstinent condition. These results may either be explained by ceiling effects of nicotine withdrawal in the abstinent condition or, may indicate reduced relative activation (smoking vs. neutral contrast) in the VS/NAc in the abstinent vs. non-abstinent conditions in this group of female smokers. © Springer Science + Business Media, LLC 2007.
Authors & Co-Authors
David, Sean P.
United Kingdom, Oxford
University of Oxford
United States, Providence
The Warren Alpert Medical School
Munafo, Marcus R.
United Kingdom, Bristol
University of Bristol
Johansen-Berg, Heidi
United Kingdom, Oxford
University of Oxford
MacKillop, James
United States, Providence
The Warren Alpert Medical School
Sweet, Lawrence H.
United States, Providence
The Warren Alpert Medical School
Cohen, Ronald A.
United States, Providence
The Warren Alpert Medical School
Niaura, Raymond S.
United States, Providence
The Warren Alpert Medical School
Rogers, Robert D.
United Kingdom, Oxford
University of Oxford
Matthews, Paul McMahan
United Kingdom, Brentford
Glaxosmithkline Plc.
Walton, Robert T.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 98
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1007/s11682-007-9004-1
ISSN:
19317557
e-ISSN:
19317565
Research Areas
Substance Abuse
Participants Gender
Female