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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Frequency of HIV type 1 dual infection and HIV diversity: Analysis of low- and high-risk populations in Mbeya Region, Tanzania
AIDS Research and Human Retroviruses, Volume 22, No. 7, Year 2006
Notification
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Description
HIV-1 diversity, frequency of recombinants, and dual infection were determined in two populations with different HIV risk behavior. A high-risk cohort of 600 female bar workers and a normal-risk population of 1108 antenatal clinic attendees and blood donors were recruited. Behavioral data were assessed and blood for HIV-1 diagnosis and genotyping was sampled. HIV-1 subtypes were defined through the multiregion hybridization assay (MHAacd). HIV-1 prevalence differed significantly among the two populations. The prevalence was 67.8% in the population of bar workers and 17% in the normal-risk population (antenatal care attendees and blood donors). Within the normal-risk population the HIV-1 prevalence was lowest in the group of volunteer blood donors. The frequency of HIV-1 infection in women was 1.7 times higher than in men. The overall subtype distribution was A (8.5%), C (40.8%), D (3.8%), AC (25.4%), AD (5.4%), CD (8.8%), and ACD (7.3%). In the high-risk population there was a higher percentage of HIV-1 recombinant strains (54% vs. 40%, p < 0.05) and a higher frequency of dual infections (19% vs. 9%, p < 0.02) compared to the normal-risk population. High-risk populations may play an important role in the evolution of HIV, as they can provide an opportunity for the virus to coinfect, recombine, and adapt to the host-specific genetic background. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Herbinger, Karl Heinz
Germany, Munich
Ludwig-maximilians-universität München
Gerhardt, Martina
Germany, Munich
Ludwig-maximilians-universität München
Piyasirisilp, Sucheep
United States, Rockville
Hjf
Mloka, Doreen A.
India
Muhimbili Univ. Coll. of Hlth. Sci.
Arroyo, Miguel A.
United States, Silver Spring
Walter Reed Army Institute of Research
Hoffmann, Oliver
Germany, Munich
Ludwig-maximilians-universität München
Maboko, Leonard L.
India, Jakarta
Ministry of Health
Birx, Deborah L.
United States, Silver Spring
Walter Reed Army Institute of Research
Mmbando, Donan W.
India, Jakarta
Ministry of Health
McCutchan, Francine E.
United States, Rockville
Hjf
Höelscher, Michael
Germany, Munich
Ludwig-maximilians-universität München
Statistics
Citations: 58
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1089/aid.2006.22.599
ISSN:
08892229
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Tanzania
Participants Gender
Male
Female