Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa
American Journal of Hematology, Volume 99, No. 1, Year 2024
Notification
URL copied to clipboard!
Description
Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that significantly contributes to childhood cancer burden in sub-Saharan Africa. Plasmodium falciparum, which causes malaria, is geographically associated with BL, but the evidence remains insufficient for causal inference. Inference could be strengthened by demonstrating that mendelian genes known to protect against malaria—such as the sickle cell trait variant, HBB-rs334(T)—also protect against BL. We investigated this hypothesis among 800 BL cases and 3845 controls in four East African countries using genome-scan data to detect polymorphisms in 22 genes known to affect malaria risk. We fit generalized linear mixed models to estimate odds ratios (OR) and 95% confidence intervals (95% CI), controlling for age, sex, country, and ancestry. The ORs of the loci with BL and P. falciparum infection among controls were correlated (Spearman's ρ = 0.37, p =.039). HBB-rs334(T) was associated with lower P. falciparum infection risk among controls (OR = 0.752, 95% CI 0.628–0.9; p =.00189) and BL risk (OR = 0.687, 95% CI 0.533–0.885; p =.0037). ABO-rs8176703(T) was associated with decreased risk of BL (OR = 0.591, 95% CI 0.379–0.992; p =.00271), but not of P. falciparum infection. Our results increase support for the etiological correlation between P. falciparum and BL risk. © 2023 Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Authors & Co-Authors
Hong, Hyokyoung Grace
United States, Washington, D.c.
United States Department of Health and Human Services
Gouveia, Mateus Henrique
United States, Bethesda
National Institutes of Health Nih
Ogwang, Martin David
Uganda, Gulu
St. Mary's Hospital Lacor - Uganda
Uganda, Kampala
African Field Epidemiology Network
Kerchan, Patrick
Uganda, Kampala
African Field Epidemiology Network
Uganda, Arua
Kuluva Hospital
Reynolds, Steven James
United States, Bethesda
National Institutes of Health Nih
Tenge, Constance Nalianya
Kenya, Eldoret
Moi University
Were, Pamela Akinyi
Kenya, Eldoret
Academic Model Providing Access to Healthcare
Kuremu, Robert Tenge
Kenya, Eldoret
Moi University
Wekesa, Walter N.
Kenya, Eldoret
Moi University
Masalu, Nestory A.
Tanzania, Mwanza
Bugando Medical Center
Kawira, Esther Lehman
Unknown Affiliation
Kinyera, Tobias
Uganda, Gulu
St. Mary's Hospital Lacor - Uganda
Uganda, Kampala
African Field Epidemiology Network
Wang, Xunde
United States, Bethesda
National Institutes of Health Nih
Leal, Thiago Peixoto
United States, Cleveland
Cleveland Clinic Foundation
Otim, Isaac Omara
Uganda, Gulu
St. Mary's Hospital Lacor - Uganda
Uganda, Kampala
African Field Epidemiology Network
Legason, Ismail D.
Uganda, Kampala
African Field Epidemiology Network
Uganda, Arua
Kuluva Hospital
Nabalende, Hadijah
Uganda, Gulu
St. Mary's Hospital Lacor - Uganda
Uganda, Kampala
African Field Epidemiology Network
Dhudha, Herry
Tanzania, Mwanza
Bugando Medical Center
Mumia, Mediatrix
Kenya, Eldoret
Academic Model Providing Access to Healthcare
Baker, Francine S.
United States, Washington, D.c.
United States Department of Health and Human Services
Okusolubo, Temiloluwa A.
United States, Bethesda
National Institutes of Health Nih
Ayers, Leona W.
United States, Columbus
The Ohio State University
Bhatia, Kishor G.
United States, Washington, D.c.
United States Department of Health and Human Services
Goedert, James Jerome
United States, Washington, D.c.
United States Department of Health and Human Services
Manning, Michelle
United States, Reston
Leidos Inc.
Cole, Nathan
United States, Reston
Leidos Inc.
Luo, Wen
United States, Reston
Leidos Inc.
Hicks, Belynda D.
United States, Reston
Leidos Inc.
Chagaluka, George
Malawi, Zomba
University of Malawi
Mutalima, Nora
United Kingdom, York
University of York
United Kingdom, Oxford
University of Oxford
Borgstein, Eric S.
Malawi, Zomba
University of Malawi
Liomba, George N.
Malawi, Zomba
University of Malawi
Kamiza, Steve B.
Malawi, Zomba
University of Malawi
Mkandawire, Nyengo C.
Malawi, Zomba
University of Malawi
Mitambo, Collins
Malawi, Lilongwe
Ministry of Health Malawai
Molyneux, Elizabeth M.
Malawi, Zomba
University of Malawi
Newton, Robert A.
United Kingdom, York
University of York
Hutchinson, Amy A.
United States, Reston
Leidos Inc.
Yeager, Meredith S.
United States, Reston
Leidos Inc.
Adeyemo, Adebowale A.
United States, Bethesda
National Institutes of Health Nih
Thein, Swee Lay
United States, Bethesda
National Institutes of Health Nih
Rotimi, Charles N.
United States, Bethesda
National Institutes of Health Nih
Chanock, Stephen J.
United States, Washington, D.c.
United States Department of Health and Human Services
Prokunina-Olsson, Ludmila V.
United States, Washington, D.c.
United States Department of Health and Human Services
Mbulaiteye, Sam M.
United States, Washington, D.c.
United States Department of Health and Human Services
Statistics
Authors: 45
Affiliations: 16
Identifiers
Doi:
10.1002/ajh.27149
ISSN:
03618609
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Multi-countries