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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The complex and diversified mitochondrial gene pool of Berber populations
Annals of Human Genetics, Volume 73, No. 2, Year 2009
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Description
The mitochondrial DNA variation of 295 Berber-speakers from Morocco (Asni, Bouhria and Figuig) and the Egyptian oasis of Siwa was evaluated by sequencing a portion of the control region (including HVS-I and part of HVS-II) and surveying haplogroup-specific coding region markers. Our findings show that the Berber mitochondrial pool is characterized by an overall high frequency of Western Eurasian haplogroups, a somehow lower frequency of sub-Saharan L lineages, and a significant (but differential) presence of North African haplogroups U6 and M1, thus occupying an intermediate position between European and sub-Saharan populations in PCA analysis. A clear and significant genetic differentiation between the Berbers from Maghreb and Egyptian Berbers was also observed. The first are related to European populations as shown by haplogroup H1 and V frequencies, whereas the latter share more affinities with East African and Nile Valley populations as indicated by the high frequency of M1 and the presence of L0a1, L3i, L4*, and L4b2 lineages. Moreover, haplogroup U6 was not observed in Siwa. We conclude that the origins and maternal diversity of Berber populations are old and complex, and these communities bear genetic characteristics resulting from various events of gene flow with surrounding and migrating populations. © Journal compilation © 2009 Blackwell Publishing Ltd/University College London.
Authors & Co-Authors
Coudray, Clotilde
France, Toulouse
Fre 2960 Cnrs
Olivieri, Anna
Italy, Pavia
Università Degli Studi Di Pavia
Achilli, A.
Italy, Pavia
Università Degli Studi Di Pavia
Italy, Perugia
Università Degli Studi Di Perugia
Pala, Maria
Italy, Pavia
Università Degli Studi Di Pavia
Melhaoui, Mohammed
Morocco, Oujda
Université Mohammed Premier Oujda
Cherkaoui, Mohamed
Morocco, Marakech
Université Cadi Ayyad
El-Chennawi, Farha Abdel Aziz
Egypt, Mansoura
Faculty of Medicine
Kossmann, Maarten
Netherlands, Leiden
Universiteit Leiden
Torroni, Antonio
Italy, Pavia
Università Degli Studi Di Pavia
Dugoujon, Jean Michel H.
France, Toulouse
Fre 2960 Cnrs
Statistics
Citations: 67
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1111/j.1469-1809.2008.00493.x
e-ISSN:
14691809
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Locations
Morocco