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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evidence for supercoughers in an analysis of six tuberculosis cohorts from China, Peru, the Gambia and Uganda
International Journal of Tuberculosis and Lung Disease, Volume 23, No. 12, Year 2019
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Description
BACKGROUND: It is very difficult to observe tuberculosis (TB) transmission chains and thus, identify superspreaders. We investigate cough duration as a proxy measure of transmission to assess the presence of potential TB superspreaders. DESIGN: We analyzed six studies from China, Peru, The Gambia and Uganda, and determined the distribution of cough duration and compared it with several theoretical distributions. To determine factors associated with cough duration, we used linear regression and boosted regression trees to examine the predictive power of patient, clinical and environmental characteristics. RESULTS: We found within-study heterogeneity in cough duration and strong similarities across studies. Approximately 20% of patients contributed 50% of total cough days, and around 50% of patients contributed 80% of total cough days. The cough duration distribution suggested an initially increasing, and subsequently, decreasing hazard of diagnosis. While some of the exposure variables showed statistically significant associations with cough duration, none of them had a strong effect. Multivariate analyses of different model types did not produce a model that had good predictive power. CONCLUSION: We found consistent evidence for the presence of supercoughers, but no characteristics predictive of such individuals. © 2019 The Union
Authors & Co-Authors
Handel, Andreas
United States, Athens
University of Georgia
Martinez, Leonardo
United States, Athens
University of Georgia
Sekandi, Juliet Nabbuye
United States, Athens
University of Georgia
Bellan, Steve E.
United States, Athens
University of Georgia
Zhu, Limei
China, Nanjing
Jiangsu Provincial Center for Disease Prevention and Control
Chen, Cheng
China, Nanjing
Jiangsu Provincial Center for Disease Prevention and Control
Liu, Qiao
China, Nanjing
Jiangsu Provincial Center for Disease Prevention and Control
Donkor, Simon A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sutherland, Jayne S.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hill, Philip C.
New Zealand, Dunedin
University of Otago
Gilman, Robert Hugh
Peru, Lima
Universidad Peruana Cayetano Heredia
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Grandjean, Louis
Peru, Lima
Universidad Peruana Cayetano Heredia
United Kingdom, London
Imperial College London
United Kingdom, London
University College London
Whalen, Christopher Curtis
United States, Athens
University of Georgia
Statistics
Citations: 3
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.5588/ijtld.18.0819
ISSN:
10273719
Research Areas
Environmental
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Gambia
Uganda