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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection
Journal of Immunology, Volume 179, No. 2, Year 2007
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Description
MyD88, the common adapter involved in TLR, IL-1, and IL-18 receptor signaling, is essential for the control of acute Mycobacterium tuberculosis (MTB) infection. Although TLR2, TLR4, and TLR9 have been implicated in the response to mycobacteria, gene disruption for these TLRs impairs only the long-term control of MTB infection. Here, we addressed the respective role of IL-1 and IL-18 receptor pathways in the MyD88-dependent control of acute MTB infection. Mice deficient for IL-1R1, IL-18R, or Toll-IL-1R domain-containing adaptor protein (TIRAP) were compared with MyD88-deficient mice in an acute model of aerogenic MTB infection. Although primary MyD88-deficient macrophages and dendritic cells were defective in cytokine production in response to mycobacterial stimulation, IL-1R1-deficient macrophages exhibited only a reduced IL-12p40 secretion with unaffected TNF, IL-6, and NO production and upregulation of costimulatory molecules CD40 and CD86. Aerogenic MTB infection of IL-1R1-deficient mice was lethal within 4 wk with 2-log higher bacterial load in the lung and necrotic pneumonia but efficient pulmonary CD4 and CD8 T cell responses, as seen in MyD88-deficient mice. Mice deficient for IL-18R or TIRAP controlled acute MTB infection. These data demonstrate that absence of IL-1R signal leads to a dramatic defect of early control of MTB infection similar to that seen in the absence of MyD88, whereas IL-18R and TIRAP are dispensable, and that IL-1, together with IL-1-induced innate response, might account for most of MyD88-dependent host response to control acute MTB infection. Copyright © 2007 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Frémond, Cécile M.C.
France, Orleans
Université D'orléans
Togbé, Dieudonnée
France, Orleans
Université D'orléans
Doz, Emilie
France, Orleans
Université D'orléans
Rose, Stéphanie
France, Orleans
Université D'orléans
Vasseur, Virginie
France, Orleans
Université D'orléans
Maillet, Isabelle
France, Orleans
Université D'orléans
Jacobs, Muazzam
South Africa, Cape Town
University of Cape Town
Ryffel, Bernhard
France, Orleans
Université D'orléans
South Africa, Cape Town
University of Cape Town
France, Orleans
Institut de Transgénose
Quesniaux, Valérie F.J.
France, Orleans
Université D'orléans
South Africa, Cape Town
University of Cape Town
France, Orleans
Institut de Transgénose
Statistics
Citations: 315
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.179.2.1178
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Genetics And Genomics