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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A myeloma hybrid producing antibody specific for an allotypic determinant on “IgD‐like” molecules of the mouse
European Journal of Immunology, Volume 7, No. 10, Year 1977
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Description
A hybrid cell line was produced by fusing a mouse myeloma line with spleen cells from BALB/c mice immunized with B10 cells. The hybrid line grew in tissue culture and in syngeneic mice and produced IgM antibody specific for “IgD‐like” molecules of mice with the Igb haplotype. The concentration of monoclonal antibody in the serum of tumor‐bearing animals reached about 2 mg/ml and gave cytotoxic titers of up to 1:800 000. The derivation of the line, some properties of the antibody secreted and the nature of its antigenic target aredescribed. Copyright © 1977 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Authors & Co-Authors
Pearson, Terry W.
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Kenya, Nairobi
International Laboratory for Research on Animal Diseases, Kenya
Galfrè, G.
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Ziegler, A.
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Milstein, César
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
Statistics
Citations: 86
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/eji.1830071006
e-ISSN:
15214141
Research Areas
Cancer
Genetics And Genomics