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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Holoendemic malaria exposure is associated with altered epstein-barr virus-specific CD8
+
T-cell differentiation
Journal of Virology, Volume 87, No. 3, Year 2013
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Description
Coinfection with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) is a major risk factor for endemic Burkitt lymphoma (eBL), still one of the most prevalent pediatric cancers in equatorial Africa. Although malaria infection has been associated with immunosuppression, the precise mechanisms that contribute to EBV-associated lymphomagenesis remain unclear. In this study, we used polychromatic flow cytometry to characterize CD8+ T-cell subsets specific for EBV-derived lytic (BMFL1 and BRLF1) and latent (LMP1, LMP2, and EBNA3C) antigens in individuals with divergent malaria exposure. No malaria-associated differences in EBV-specific CD8+ T-cell frequencies were observed. However, based on a multidimensional analysis of CD45RO, CD27, CCR7, CD127, CD57, and PD-1 expression, we found that individuals living in regions with intense and perennial (holoendemic) malaria transmission harbored more differentiated EBV-specific CD8+ T-cell populations that contained fewer central memory cells than individuals living in regions with little or no (hypoendemic) malaria. This profile shift was most marked for EBV-specific CD8+ T-cell populations that targeted latent antigens. Importantly, malaria exposure did not skew the phenotypic properties of either cytomegalovirus (CMV)-specific CD8+ T cells or the global CD8+ memory T-cell pool. These observations define a malaria-associated aberration localized to the EBV-specific CD8+ T-cell compartment that illuminates the etiology of eBL. © 2013, American Society for Microbiology.
Authors & Co-Authors
Chattopadhyay, Pratip K.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Chelimo, Kiprotich
Kenya, Nairobi
Kenya Medical Research Institute
Embury, Paula B.
United States, Cleveland
Case School of Medicine
Mulama, David Hughes
Kenya, Nairobi
Kenya Medical Research Institute
Sumba, Peter Odada
Kenya, Nairobi
Kenya Medical Research Institute
Gostick, Emma
United Kingdom, Cardiff
Cardiff University
Ladell, Kristin
United Kingdom, Cardiff
Cardiff University
Brodie, Tess M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Vulule, John M.
Kenya, Nairobi
Kenya Medical Research Institute
Roederer, Mario
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Moormann, Ann M.
United States, Worcester
University of Massachusetts Chan Medical School
Price, David Ashley
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United Kingdom, Cardiff
Cardiff University
Statistics
Citations: 35
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1128/JVI.02158-12
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases