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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration
AIDS, Volume 13, No. 4, Year 1999
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Description
Objectives: This study was undertaken to determine the relative effect of malaria infection on HIV concentration in blood plasma, and prospectively to monitor viral concentrations after antimalarial therapy. Design: A prospective, double cohort study was designed to compare the blood HIV-1 RNA concentrations of HIV-positive individuals with and without acute malaria illness. Subjects were followed for 4 weeks after successful malaria therapy, or for 4 weeks from enrollment (controls). Methods: Malawian adults with symptomatic Plasmodium falciparum parasitemia (malaria group) and asymptomatic, aparasitemic blood donors (control group) were tested for HIV-1 antibodies to identify appropriate study groups. The malaria group received antimalarial chemotherapy only and were followed with sequential blood films. In both groups, blood plasma HIV-1 RNA viral concentrations were determined at enrollment and again at 1, 2 and 4 weeks. Results: Forty-seven malaria patients and 42 blood donors were enrolled. At enrollment blood plasma HIV-1 RNA concentrations were approximately sevenfold higher in patients with malaria than in blood donors (medians 15.1 × 104 and 2.24 × 104 copies/ml, respectively, P = 0.0001). No significant changes in median HIV-1 concentrations occurred in the 21 blood donors followed to week 4 (P = 0.68). In the 27 subjects successfully treated for malaria who were followed to week 4, a reduction in plasma HIV-1 RNA was observed from a median of 19.1 × 104 RNA copies/ml at enrollment, to 12.0 × 104 copies/ml at week 4, (P = 0.02). Plasma HIV-1 concentrations remained higher in malaria patients than controls (median 12.0 × 104 compared with 4.17 × 104 copies/ml, P = 0.086). Conclusions: HIV-1 blood viral burden is higher in patients with P. falciparum malaria than in controls and this viral burden can, in some patients, be partly reduced with antimalarial therapy. © 1999 Lippincott Williams & Wilkins.
Authors & Co-Authors
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Chapel Hill
Unc Health
Jere, Charles S.
Malawi, Zomba
University of Malawi
Taylor, Terrie Ellen
United States, East Lansing
Msu College of Osteopathic Medicine
Munthali, Peter
Malawi, Zomba
University of Malawi
Dyer, John R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Wirima, Jack J.
Malawi, Zomba
University of Malawi
Rogerson, Stephen J.
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Kumwenda, Newton I.
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Eron, Joseph J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Fiscus, Susan A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Chakraborty, Hrishikesh
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Taha, Taha E.
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Molyneux, Malcolm Edward
Malawi, Blantyre
Queen Elizabeth Central Hospital Malawi
Statistics
Citations: 275
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1097/00002030-199903110-00007
Research Areas
Cancer
Infectious Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative