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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Increase in the detection rate of viral and parasitic enteric pathogens among Egyptian children with acute diarrhea
Journal of Infection in Developing Countries, Volume 6, No. 11, Year 2012
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Description
Introduction: Acute diarrhea continues to be a major cause of morbidity and mortality in children from developing countries. Determination of the frequency of diarrhea in an area, along with the proportion of disease caused by specific enteric agents of different origins, is considered the first step in controlling diarrheal diseases. Methodology: From 2005 to 2007, a hospital-based surveillance was conducted in two locations in Egypt to determine the causes of acute diarrhea in children younger than 5-years seeking treatment. Five additional enteric viral and parasitic pathogens were tested using commercially-available enzyme immunoassays (EIA) to re-evaluate the prevalence of diarrheal pathogens in undiagnosed cases. Results: Adenovirus, astrovirus, norovirus and G. lamblia were detected as the sole pathogen in 2% (n=34), 3% (n=56), 9% (n=191) and 7% (n=146) of the cases, respectively. E. histolytica was never detected as the sole pathogen. The percentage of diarrheal cases with a known cause increased significantly, from 48% (n=1,006) to 74% (n=1,568) (P<0.0001). Conclusion: In our study, the incorporation of immunoassays yielded useful data in identifying pathogens in previously pathogen-negative diarrhea cases. © 2012 El-Mohammady et al.
Authors & Co-Authors
El-Mohammady, Hanan
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Mansour, Adel Mahmoud
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Shaheen, Hind Ibrahim
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Henien, Nagwa Hanna
Egypt, Cairo
Egyptian Ministry of Health and Population
Motawea, Mohamed Salah
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Rafaat, Ismail
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Moustafa, Manal
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Adib-Messih, Ibrahim
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Italy, Siena
Novartis Vaccines and Diagnostic S.r.l.
Sebeny, Peter J.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Young, Sylvia Y.N.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Klena, John David
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 33
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.3855/jidc.2349
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Egypt