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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HCV infection among saudi population: High prevalence of genotype 4 and increased viral clearance rate
PLoS ONE, Volume 7, No. 1, Article e29781, Year 2012
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Description
HCV is a major etiological agent of liver disease with a high rate of chronic evolution. The virus possesses 6 genotypes with many subtypes. The rate of spontaneous clearance among HCV infected individuals denotes a genetic determinant factor. The current study was designed in order to estimate the rate of HCV infection and ratio of virus clearance among a group of infected patients in Saudi Arabia from 2008 to 2011. It was additionally designed to determine the genotypes of the HCV in persistently infected patients. HCV seroprevalence was conducted on a total of 15,323 individuals. Seropositive individuals were tested by Cobas AmpliPrep/Cobas TaqMan HCV assay to determine the ratio of persistently infected patients to those who showed spontaneous viral clearance. HCV genotyping on random samples from persistently infected patients were conducted based on the differences in the 5′untranslated region (5′UTR). Anti-HCV antibodies were detected in 7.3% of the totally examined sera. A high percentage of the HCV infected individuals experienced virus clearance (48.4%). HCV genotyping revealed the presence of genotypes 1 and 4, the latter represented 97.6% of the tested strains. Evidences of the widespread of the HCV genotype 4 and a high rate of HCV virus clearance were found in Saudi Arabia. © 2012 Abdel-Moneim et al.
Authors & Co-Authors
Abdel-Moneim, Ahmed Sayed
Saudi Arabia, Taif
Taif University
Egypt, Beni Suef
Faculty of Veterinary Medicine
Bamaga, Mohammad S.
Saudi Arabia, Taif
Al Hada Armed Forces Hospital
Shehab, Gaber M.G.
Saudi Arabia, Taif
Taif University
Egypt, Giza
Faculty of Agriculture
Abu-Elsaad, Abdel Aziz S.A.
Saudi Arabia, Taif
Taif University
Egypt, Beni Suef
Faculty of Sciences
Farahat, Fayssal Mostafa
Saudi Arabia, Taif
Armed Forces Hospitals
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Statistics
Citations: 43
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0029781
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study