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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Proline homozygosity in codon 72 of TP53 is a factor of susceptibility to nasopharyngeal carcinoma in Tunisia
Cancer Genetics and Cytogenetics, Volume 178, No. 2, Year 2007
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Description
A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline. These variants may be associated with tumor susceptibility since they interfere with the ability of TP53 to activate apoptosis, and might account for ethnic variation in cancer frequency. Using a polymerase chain reaction-restriction fragment length polymorphism assay, we tested peripheral blood samples from 115 patients with nasopharyngeal carcinoma (NPC) and from 83 healthy individuals. Patients with NPC (Arg/Arg = 38.26%, Arg/Pro = 41.73%, and Pro/Pro = 20%) showed a significantly different percentage of the Pro/Pro genotype, compared with the control population (Arg/Arg = 39%, Arg/Pro = 54%, and Pro/Pro = 7%) (P = 0.0307). No significant difference was observed between TP53 codon 72 polymorphism and age, sex, histological grade, and metastasis. These results provide evidence that individuals with the Pro/Pro genotype have an increased risk of developing NPC in Tunisia. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Hadhri-Guiga, Boutheina
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Toumi, Nabil
Tunisia, Sfax
Chu Habib Bourguiba
Khabir, Abdelmajid
Tunisia, Sfax
Chu Habib Bourguiba
Sellami-Boudawara, Tahiya
Tunisia, Sfax
Chu Habib Bourguiba
Ghorbel, Abdelmonem
Tunisia, Sfax
Chu Habib Bourguiba
Daoud, Jamel L.
Tunisia, Sfax
Chu Habib Bourguiba
Frikha, Mounir F.
Tunisia, Sfax
Chu Habib Bourguiba
Gargouri, Ali Faouzi
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Mokdad-Gargouri, Raja
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Statistics
Citations: 26
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/j.cancergencyto.2007.05.013
ISSN:
01654608
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Tunisia